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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Cancer immunotherapy based on the combination of TLR ligands and ligands of phagocytic receptors
 UHER, Ondřej
The main goal of this thesis was to study cancer immunotherapy based on combination of TLR ligands and ligands of phagocytic receptors. We studied replacement of LPS by bacterium Borrelia burgdorferi or Resiquimod in cancer immunotherapy. We also tried to block CD47 in cancer immunotherapy. The last aim of this thesis was phosphatidylserine expression on melanoma cells B16-F10.
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Histologic analysis of melanoma B16-F10 therapy by agonist of TLRs and fagocyte receptors
 DIVOKÁ, Petra
The aim of submited Thesis was to contribute to illustration on effect of TLR and fagocytate receptors in melanoma B16-F10 treatment with mouse model. Currently, a consequence of different ligands of fagocyte receptors and their combination with liposacharide (LPS) was tested. Ligands of fagocytate receptors was used in form enabled inside tumor cells anchoring. It deals with these compounds: f-MLFKK-BAM4000, laminarin-BAM4000, mannan-BAM4000. Gained results confirmed that previously observed huge synergy of LPS (activation of TLR4) and activation of phagocytic receptors by ligands anchored to tumor cells found the clarification in the form of extensive necrotization of tumor mass at the histological level.
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