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Fungal metabolism modulation by plant substances
Sedláková, Vendula ; Čmoková, Adéla (advisor) ; Kolařík, Miroslav (referee)
Phytochemicals are bioactive substances by which plants affect organisms in their vicinity. Fungi often respond to their presence by metabolism alternation, which is manifested by the production of secondary metabolites, an increase in biomass or the regulation of virulence. These changes can be caused by phytochemicals (e.g. curcumin, EGCG) with abilities to modulate epigenetic information. The first half of the work is devoted to mechanisms of epigenetic modification (e.g. methylation, histone modification), which were studied in fungi. The second half summarizes studies focused on phytochemicals, in which the ability to modify epigenetic information in eukaryotic organisms was observed. The bachelor's thesis thus brings valuable knowledge about the possibility of modifying fungal metabolism by phytochemicals, which are often waste products of industry. Information summarized in this work can have a significant impact on improving biotechnological processes, where there is an effort to increase biomass yield or induce the production of secondary metabolites in cases where their production is normally suppressed. Key words: secondary metabolites, epigenetics, epigenetic modification, phytochemicals, filamentous fungi
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Health importance of phytochemicals in berries focused on weight-reducing diet
VOKOUNOVÁ, Kateřina
Bachelor´s thesis named "Health importance of phytochemicals in berries focused on weight-reducing diet" deals with the weight-reducing diet containing phytochemicals and its health effect on human heatlh. In theoretical part of the thesis, I focused on weight-reducing diet and bioactive substances, and I described phytochemicals and blueberries in detail. The formation of a two-week weight-reducing diet containing polyphenols correspondig with the amount of 120 ml natural blueberries a day was the goal of my thesis. The exploration of food products as fully-fledged sources of polyphenols was my next goal. For the processing of the research I have examined food products containing blueberries, which were made in the South Bohemian region, specifically through interviews with leaders and representatives of various companies and I found all the necessary information about each food products containing blueberries. The amount of polyphenols was determined by HPLC (High Performance Liquid Chromatography) which was conducted under the leadership of doc. MUDr. Petr Petr, Ph.D. I finished counting the amount of polyphenols in some food products from the initial analysis. I have included these products in the weight-reducing diet with any possible adjustments to meet the criteria of weight-reducing diet. I included natural blueberries in many meals in various modifications. The richest sources of natural polyphenols were frozen blueberries and beverages containing natual blueberries. There were natural blueberries refrigerated or frozen, Herbal tea with blueberries or dairy products containing blueberries the most appropriate for the weigt-reducing diet.
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