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Modeling of the thermal effects on living tissue during electroporation process
Kafka, Roman ; Cipín, Radoslav (referee) ; Červinka, Dalibor (advisor)
The work deals with the current state of knowledge of heat transfer in living tissue. It is described here what the distribution of heat is affected with and the existing calculation options. For solving Pennes equation using finite element method COMSOL Multiphysics 5.4 is used. From the current state of the published studies, three are selected and described, each using a different approach. Based on the benefit of each of the studies described, a simple model of its own that simulates an ablation catheter attached to cardiac tissue is solved. A change in electrical conductivity as a function of the electric field intensity is taken into account, but there is also a comparison with anisotropic tissue that has electrical conductivity in different directions. The result of the calculation is voltage distribution, density of electric current and losses, temperature distribution in the model at several time points and graph of temperature development over time.
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Modeling of the thermal effects on living tissue during electroporation process
Kafka, Roman ; Cipín, Radoslav (referee) ; Červinka, Dalibor (advisor)
The work deals with the current state of knowledge of heat transfer in living tissue. It is described here what the distribution of heat is affected with and the existing calculation options. For solving Pennes equation using finite element method COMSOL Multiphysics 5.4 is used. From the current state of the published studies, three are selected and described, each using a different approach. Based on the benefit of each of the studies described, a simple model of its own that simulates an ablation catheter attached to cardiac tissue is solved. A change in electrical conductivity as a function of the electric field intensity is taken into account, but there is also a comparison with anisotropic tissue that has electrical conductivity in different directions. The result of the calculation is voltage distribution, density of electric current and losses, temperature distribution in the model at several time points and graph of temperature development over time.
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