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Studium imunitní paměti při imunoterapii pankreatického adenokarcinomu
DANIELOVÁ, Kristýna
This thesis is focused on immunotherapeutic strategy of pancreatic adenokarcinoma based on combination of TLR agonists, the ligands stimulating phagocytosis and monoclonal antibody anti-CD40. The aim of this thesis was to analyze the memory subpopulations of the T lymphocytes and efficacy of isolated CD3+ T lymphocytes from cured mice on pancreatic adenocarcinoma cell attachment.
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Imunoterapie pankreatického adenokarcinomu a jeho metastáz
FREJLACHOVÁ, Andrea
This thesis is focused on immunotherapy of pancreatic adenocarcinoma which is based on the synergy of TLR agonists with the ligands stimulating phagocytosis. The aim of this thesis was to analyze the infiltration of immune cells in untreated metastasis, to study the combination therapy of metastasis, and to look for ways to increase the effect of cancer immunotherapy. Panc02, the murine pancreatic adenocarcinoma model, was used for the experiments.
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Imunoterapie metastazujícího pankreatického adenokarcinomu řešená na dvounádorovém modelu
SKALIČKOVÁ, Markéta
This master's thesis studies the efficacy of cancer immunotherapy based on TLR agonists and ligands stimulating phagocytosis, abbreviated as MBTA therapy, using a mouse model of pancreatic adenocarcinoma. The main goals are: (1) to enhance the efficacy of MBTA in the case of large tumors, (2) to enhance the efficacy of MBTA using a bilateral pancreatic adenocarcinoma mouse model, (3) to examine the potential of lipoteichoic acid to opsonize cancer cells and stimulate phagocytic cells.
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Analýza imunitních procesů při nádorové imunoterapii založené na synergii agonistů TLR a ligandů stimulujících fagocytózu
UHER, Ondřej
This thesis is focused on analysis of immune processes during cancer immunotherapy which is based on synergistic combination of TLR agonists and phagocytosis stimulating ligands anchored into the tumour cell membrane. This immunotherapy was tested in murine melanoma B16-F10 and murine pancreatic adenocarcinoma Panc02 models. The aims of this thesis were to analyse the tumor infiltration, elucidate the role of innate immunity in this immunotherapy, and study the possibility of strengthening immunotherapeutic effect using anti-CD40 and anti-CTLA-4.
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