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Verification of stable next generation networks via transmission parameters measurement
Gregor, Lukáš ; Čučka, Milan (referee) ; Grenar, David (advisor)
This thesis deals with the measurement of transmission parameters in the new generation access networks NGA. The aim of the thesis is to build and configure a test network and scenarios for the measurement of service quality parameters and then verify the transmission stability. The theoretical part describes general functioning of NGN networks, the requirements of different telecommunications services on quality parameters, methodology and recommendations for measuring transmission parameters in packet networks. The practical part deals with the configuration of scenarios using mainly MPLS technology and methodology of their testing. Measurements were performed according to recommendations IETF RFC 2544, IETF RFC 6349 with the ExacTCP test and ITU-T Y.1564 with the EtherSAM test. For measurements were used measuring instruments of EXFO brand. In conclusion, the measurement results according to the mentioned standards were evaluated and also the advantages of using the measurement according to the given standard in NGA access networks were discussed.
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Effects of the Interferon regulatory factor 3 on immune responses to vaccinia virus in the atopic organism
Pilná, Hana ; Mělková, Zora (advisor) ; Drbal, Karel (referee)
Vaccinia virus (VACV) is an enveloped DNA virus, member of the Orthopoxviridae genus. VACV genome size is about 200 kbp. This huge genome capacity allows VACV to encode a set of factors that are non-essential for virus replication and spread in vitro. While these factors are needed for interfering with host immune responses, VACV remains strongly immunogenic. Cell-mediated and humoral immune responses in atopic disorders are deregulated to a certain extent, leading to complications in case of infection or vaccination with vaccines based on replicating viruses, such as eczema vaccinatum caused by VACV. VACV effects on immune responses consist among others in the inhibition of expression of type I interferon (IFN) at various levels - for example in a specific inhibition of phosphorylation of the interferon regulatory factor-3 (IRF-3) via inhibition of the activity of TANK-binding kinase 1 (TBK 1) that normally phosphorylates IRF-3. Phosphorylation allows IRF-3 to translocate into the nucleus where it initiates transcription of IFNβ followed by induction of expression of IFN and interferon stimulated genes. Expression of these genes is shut down when IRF-3 activity is inhibited. To overcome this block, a recombinant VACV expressing murine IRF-3 under VACV p7.5 promotor (WR-IRF3) was generated....
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Verification of stable next generation networks via transmission parameters measurement
Gregor, Lukáš ; Čučka, Milan (referee) ; Grenar, David (advisor)
This thesis deals with the measurement of transmission parameters in the new generation access networks NGA. The aim of the thesis is to build and configure a test network and scenarios for the measurement of service quality parameters and then verify the transmission stability. The theoretical part describes general functioning of NGN networks, the requirements of different telecommunications services on quality parameters, methodology and recommendations for measuring transmission parameters in packet networks. The practical part deals with the configuration of scenarios using mainly MPLS technology and methodology of their testing. Measurements were performed according to recommendations IETF RFC 2544, IETF RFC 6349 with the ExacTCP test and ITU-T Y.1564 with the EtherSAM test. For measurements were used measuring instruments of EXFO brand. In conclusion, the measurement results according to the mentioned standards were evaluated and also the advantages of using the measurement according to the given standard in NGA access networks were discussed.
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