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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Comparison of reflex-based and operant methods when evaluating effects of treatment on pain in experimetnal models
 Panušková, Kristýna ; Vaculín, Šimon (advisor) ; Šustková, Magdaléna (referee)
Pharmacological treatment of neuropathic pain is still insufficient. Methylphenidate, a psychostimulant that increases the dopamine and noradrenaline levels, is commonly used for treating ADHD. There have been reports of changes in patients pain thresholds by ADHD patients treated with methylphenidate. The aim of the study is to examine if methylphenidate can affect peripheral neuropathic pain. Neuropathic pain has been modelled on laboratory rats by chronic constriction of the ischiatic nerve. The effect of methylphenidate on the evoked pain component was evaluated on control animals and on animals with neuropathic pain using reflex (plantar test, vonFrey test) and operanting test (thermal place preference). The effect of methylphenidate on the spontaneous components of pain was evaluated using the methods of conditioned place preference. This study has proven that methylphenidate in an applicable dose of 1 mg/kg has an antialodynic effect but does not act antinociceptively. This study further confirms that methylphenidate in low doses does not act as attractant and has no effect on spontaneous pain. The last part of the study compares the different methods for pain measurement and comes to the conclusion that the plantar test is not an adequate method for evaluating the effect of analgesics...
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Options possible use of methylphenidate as a substitution substance in addiction to methamphetamine
 Petrlová, Ivana ; Šejvl, Jaroslav (advisor) ; Minařík, Jakub (referee)
Methamphetamine is currently a leading addictive substance abused by problem drug users on the Czech drug scene. The number of problem drug users of methamphetamine accounts for approximately 73 % of all problem drug users and most of them use methamphetamine for injection. There is no approved effective pharmacotherapy for methamphetamine addiction worldwide. A major benefit for users of methamphetamine due to their number and risks that problem and injecting drug use bring could be substitution treatment such as opiate addiction. Even though there are a few doctors in the Czech republic, who prescribe amphetamine-type drugs to patients diagnosed by F15.2. as a substitution substances, no substance is widely accepted and extended. One of those compounds is methylphenidate hydrochloride known under the trade names Ritalin® and Concerta® .The possibilities of using these substances will be dealt with in my bachelor thesis. The aim of this bachelor thesis is to map out up-to-date knowledge of the use of methylphenidate as a substitution substance in addiction to methamphetamine and describing the possibilities of its potential use for substitution therapy. The bachelor thesis has a research character and works with monographs, published articles and clinical studies dealing with the given issue. The...
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