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Molecules involved in immune evasion encoded within the US2-US11 genomic region of human cytomegalovirus
Kroutilová, Marie ; Němečková, Šárka (advisor) ; Lichá, Irena (referee)
Human cytomegalovirus (HCMV) from the family Herpesviridae causes lifelong latent infections in immunocompetent patients. HCMV encodes multiple molecules which interfere with host immune responses, thus helping the virus to escape from them and persist in the host. Inhibition of antigen presentation by MHC class i glycoproteins is an important immune evasion mechanism, which enables the virus to protect infected cells from recognition by CD8+ T lymphocytes. Most of the molecules inhibiting MHC class i presentation is encoded withing the US2 to US11 region of HCMV genome, including five glycoproteins (US2, US3, US6, US10 a US11) and one miRNA (US4-1). gpUS2 and gpUS3 are also able to block MHC class II antigen presentation and supress the response of CD4+ T lymphocytes. This thesis summarises current knowledge about the immune evasion molecules encoded within the US2-US11 genomic region of HCMV. Keywords: human cytomegalovirus (HCMV), immune evasion, MHC I, MHC II, US2, US3, US4-1, US6, US10, US11
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