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Quantitative fMRI as a biomarker in prodromal dementia with Lewy bodies
Venhudová, Aneta ; Mikl, Michal (referee) ; Gajdoš, Martin (advisor)
Dementia with Lewy bodies (DLB) is one of the most common neurodegenerative diseases. With the aging population trend observed in today's society, an increasing prevalence of such diseases is expected. Since the symptoms of various neurodegenerative diseases can be similar but their causes are different, their treatments also vary. It is therefore important to accurately diagnose patients and apply the appropriate therapeutic approach. Early detection of Dementia with Lewy bodies (DLB) symptoms allows an earlier diagnosis, which enables pacients to start with therapy sooner, improving their quality of life with the disease. This bachelor's thesis focuses on use of quantitative fMRI in detection of the prodromal stage of DLB. The theoretical research shortly introduces the issue of DLB, dynamic functional connectivity, the principles of MR Imaging and discusses discriminant analysis methods. In the practical section data of subjects in the prodromal stage of DLB as well as healthy controls are visualized and an algorithm for comparing a new experimental approach to fMRI data processing with the metod, which is being currently used, is proposed, implemented and described. The results of the comparison are discussed.
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