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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
The effect of tick cystatins on TLR - induced maturation of myeloid dendritic cells
 NERADOVÁ, Hana
Tick saliva contains a lot of molecules with antihemostatic and immunosupressive effects.The goal of this thesis is to test the effects of tick salivary cystatins from I.ricinus and I.scapularis on TLR - induced maturation of bone-marrow derived dendritic cells and production of chosen cytokines. Over all, the supressive effect of tick cystatins was observed in relation to TLR-induced maturation of DC. In addition, cystatins enhanced production of IL-10 and attenuated induction of IL-12 cytokines.
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Optimization of melanoma immunotherapy based on the anchoring of laminarin on the surface of tumor cells
 ŠVECOVÁ, Ivana
The aim of this thesis was to find optimal anticancer regimen of therapy, based on a naturally occuring polysaccharide laminarin. It was studied on the Mus musculus skin melanoma B16-F10. There were explored an ajuvant effect of LTA. Mixture of laminarin with LPS was applied with various anchorings and was tryed out the possible replacement of LPS. Using the flow cytometry there were determined progress of immune cells during application. This therapy resulted in reduction of tumor volume and the prolongation of overall survival.
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