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Use of thrombolytics in prehospital emergency care
OHNESORG, Adam
The topic of this bachelor thesis is the use of thrombolytics in pre-hospital care.The theoretical part is focused on the anatomy and physiology of the cardiovascular system. The work presents recent information on anticoagulants, antiaggregants and indications for thrombolysis in pre-hospital care.The practical part of the bachelor's thesis was processed through a qualitative investigation, where semi-structured interviews were used. 13 paramedics from the Karlovy Vary region were involved in the research. The aim of the research was to find out the level of awareness of the paramedics about the issue of thrombolysis in pre-hospital care and to detect practical and theoretical obstacles to its use. The research investigation took place in March 2023. Each informant underwent the interview voluntarily. The resulting data from the interviews were analyzed and coded in the thesis. Subsequently, the data was divided into categories and subcategories. Two research questions were set in the research investigation. The first question focused on the awareness of paramedics about the possibilities of using thrombolytics in pre-hospital care. The second research question addressed barriers to use from a paramedic perspective. Among the obstacles, paramedics also included the small number of cases that require the use of thrombolytics and the resulting limited experience of doctors and paramedics. The main indication for the administration of thrombolytics in pre-hospital care is sudden the use of thrombolysis in acute myocardial infarction is not practically used. Paramedics demonstrated a not good awareness of the indications for thrombolysis and the risks associated with its administration. Due to the very rare administration of thrombolysis in pre-hospital care, it is certainly appropriate to carry out regular training on this issue for both paramedics and EMS doctors.
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The role of succinic acid in cardiac ischemic tolerance in rats
Kordač, Petr ; Neckář, Jan (advisor) ; Husková, Zuzana (referee)
Succinate is one of the intermediate in the Krebs cycle, which in recent years has been shown to interfere with other cellular events, some of which may affect cardiac ischemic tolerance. The aim of this project was to clarify its cardioprotective role in rat hearts subjected to acute ischemia-reperfusion. The myocardial resistance to acute ischemia (infarct size and incidence and severity of ischemic and reperfusion arrhythmias) was analyzed using the Langendorff method of isolated perfused heart at a constant flow with acute succinate administration. Local ischemia was induced by ligation of left anterior descending coronary artery. Acute administration of 1 mM succinate before 60 minutes of ischemia or before reperfusion only had a beneficial effect on reducing the infarct size by 25-30 % compared to the control group. At the same time, it had an adverse effect on the incidence and severity of ischemic and reperfusion arrhythmias. Key words: Succinate, heart, rat, heart-attack, ventricular arrhythmias
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Insurance of serious illnesses
Rezek, Vojtěch ; Ducháčková, Eva (advisor) ; Černochová, Martina (referee)
This bachelors thesis deals with the insurance of serious illnesses and its significance in the insurance market in the Czech Republic. Firstly, the thesis outlines the basic characteristics of this insurance and the types of serious illnesses it covers. In addition, the history of the development of this type of insurance in the world insurance market and its use in the Czech environment is briefly discussed. Furthermore, this dissertation lists the technical parameters of the insurance in the insurance contract and their practical utilization. Moreover, the specifics of the most serious illnesses from multiple expert perspectives are discussed, followed by examining the modern trends in this insurance policy. The second part of this thesis analyses statistical data on the number of diagnoses and deaths of serious illnesses in a given period of time, thus determining the frequency of these illnesses. Additionally, state financial support in cases of serious illnesses is discussed. The thesis concludes with the calculations of the insurance premiums in serious illness insurance, comparing different insurers and the amount of indemnity in the given period. The aim of this dissertation is to analyse the statistical data concerning the insurance of serious illnesses, affirming the importance of obtaining insurance of this health risk in life insurance contracts on the basis of the analysis carried out in the practical part of the thesis.
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