National Repository of Grey Literature 1 records found  Search took 0.02 seconds. 
Molecular Genetic Diagnostics of Pediatric high-grade Gliomas
KALENDOVÁ, Tereza
Pediatric high-grade gliomas (HGG) represent a serious disease with high morbidity and mortality rates in children. Genetic diagnostics are becoming a key tool for better understanding the pathogenesis of these tumors and improving their clinical management. This bachelor's thesis focuses on the molecular genetic diagnosis of HGG in pediatric patients. The thesis begins with an overview of pediatric HGG and the importance of a molecular genetic approach to their study. It then evaluates current molecular genetic techniques in the diagnosis of HGG, primarily focusing on the analysis of specific gene mutations. Furthermore, the thesis addresses methods of sample collection, data analysis, and interpretation of results. Emphasis is placed on the potential of molecular genetic diagnostics for predicting prognosis, selecting appropriate therapeutic strategies, and monitoring patients post-treatment. Finally, challenges and future directions in the field of molecular genetic diagnostics of HGG in pediatric patients are discussed. This work provides a comprehensive view of the significance of molecular genetics in the diagnosis and management of HGG in children and contributes to the development of new approaches to treating this serious disease.

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