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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Mechanisms of origin of cryptic rearrangements in human chromosomes and its clinical associations
 Šenkyřík, Pavel ; Šolc, Roman (advisor) ; Drábová, Jana (referee)
Chromosomal rearrangements are one of the processes which leads to formation of genetic disorders. Among the mechanisms that cause the rearrangements belong NAHR, NHEJ, FoSTeS and MMBIR. They generate rearrangements of many types and have different requirements for their realization. NAHR is recombination-based mechanism responsible for recurrent rearrangements and operates mainly in repetitive sequences. NHEJ is used for repair of double-strand breaks and generates non-recurrent rearrangements due to its error rate. FoSTeS and MMBIR are replication-based mechanisms able to make both complex rearrangements and less massive non-recurrent rearrangements. Architecture of DNA has influence on all above-mentioned mechanisms. Structures that affect course or effectivity of mechanisms are microhomologies, double-strand breaks, tandem repetitions, hairpins, and loops causing stalling of replication fork.
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