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Maternal separation and its impact on neurotransmitter systems of the brain
Přítulová, Eliška ; Novotný, Jiří (advisor) ; Černá, Barbora (referee)
Adverse early life stress conditions during the postnatal period can alter normal brain and neuroendocrine system development and increase the susceptibility of the individual to various disorders. Material separation is a model used to investigate the effects of early life stress on organism. The principle of this model is to provoke the stress of the infant by disrupting its contact with the mother, which is important for its proper development. The aim of this paper is to unify the existing knowledge about the impact of maternal separation on signaling pathways in the brain and to outline the directions of future research. Despite all the differences between the individual studies, there is a basic finding that maternal separation leads to deficits in the functions of important neurotransmitter systems, can induce long-term changes in different brain signaling pathways and can be accompanied by changes at the neuroendocrine and behavioral levels.

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