Home > Search Results: keywords:"Duktální adenokarcinom pankreatuKolorektální karcinomHepatocelulární karcinomImunohistochemieSekvenování nové generace"
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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Histopathology and Molecular Biology of Gastrointestinal Tumours
 Červenková, Lenka ; Souček, Pavel (advisor) ; Eckschlager, Tomáš (referee) ; Pivovarčíková, Kristýna (referee)
The incidence and mortality of gastrointestinal cancers are at a level that represents a serious problem. These tumours have non-specific clinical symptoms, which often results in late diagnosis. In recent years, there have been significant advances in the identification and monitoring of molecular markers of tumour changes in the diagnosis, prognosis and treatment of these diseases. However, clinical oncology still faces a shortage of such biomarkers. The aim of this study was to find new biomarkers that correlate especially with prognostic indicators and predictors of treatment response or chemoresistance in gastrointestinal tract cancers. This thesis is based on 5 studies addressing ductal adenocarcinoma of the pancreas, colorectal cancer and hepatocellular carcinoma using IHC and molecular methods. All studies were performed using archival formalin-fixed paraffin-embedded samples. The main results include immunohistochemical evidence of protein expression of MRP2, SLC22A3 and SUR1/ABCC8 transporters and its significant association with the prognosis of pancreatic adenocarcinoma. Patients without SLC22A3 protein expression in the apical membrane were found to have significantly shorter disease-free and overall survival. We found longer disease-free survival in patients with positive membrane...
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