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Design of Mobile X-Ray Scanner
Stejskal, Pavel ; Chorý, Tomáš (referee) ; Křenek, Ladislav (advisor)
Master thesis deals with creating a new design of mobile x-ray machine. Three studies of design were created on the base of processed analysis, when the best one were chosen and developed as a final design. The final design takes into account all egonomics and technical requirements and creates a machine with less technical and more favorable view for patients. Simplification and better arranged the control panels bring easier service for operators.
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Synthesis of chelators for use in diagnostic imaging
Kretschmer, Jan ; Polášek, Miloslav (advisor) ; Kubíček, Vojtěch (referee) ; Hrubý, Martin (referee)
Metals play a crucial role in medicine as a part of therapeutic or diagnostic preparations. However, in the majority of cases, their properties cannot be utilized entirely in free ionic form. Organic molecules capable of chelation are used to open the full potential of the metal. The molecules are called chelators and are the core theme of this thesis. The most important function of these molecules is the chelation and coordination of the metal, but chelators can provide other important functionalities. This work, therefore, focuses on the design, synthesis, and application of such polyfunctional chelators and is divided into two parts: DO3A-Hyp This part of the thesis deals with chelators that can be used as amino acids to incorporate lanthanides into peptides. The developed chelators provide a short and rigid connection of the metal to the peptide chain. Tripeptides containing two units of such chelators with a central amino acid bearing a CF3 group were synthesized to demonstrate the capability of DO3A-Hyp building blocks. Two paramagnetic metals were combined within this tripeptide, and it was shown that such a rigid and locked system could be used for combining their magnetic susceptibility tensors. These magnetic susceptibility tensors were used for manipulation of the 19 F NMR shift of the CF3...
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Design of Mobile X-Ray Scanner
Stejskal, Pavel ; Chorý, Tomáš (referee) ; Křenek, Ladislav (advisor)
Master thesis deals with creating a new design of mobile x-ray machine. Three studies of design were created on the base of processed analysis, when the best one were chosen and developed as a final design. The final design takes into account all egonomics and technical requirements and creates a machine with less technical and more favorable view for patients. Simplification and better arranged the control panels bring easier service for operators.
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Design of Mobile X-Ray Scanner
Stejskal, Pavel ; Křenek, Ladislav (advisor)
Master thesis deals with creating a new design of mobile x-ray machine. Three studies of design were created on the base of processed analysis, when the best one were chosen and developed as a final design. The final design takes into account all egonomics and technical requirements and creates a machine with less technical and more favorable view for patients. Simplification and better arranged the control panels bring easier service for operators.
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