National Repository of Grey Literature 895 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
The role of Kit ligands in hematopoiesis of Danio rerio
Oltová, Jana
Hematopoiesis is a precisely regulated process, dependent on the activity of hematopoietic cytokines and their receptors. Due to an extra round of whole genome duplication in teleost fish, two paralogs of many important genes, including some hematopoietic cytokines and their receptors, are present in the zebrafish (Danio rerio) genome. In this project, we have been investigating the role of zebrafish Kit ligands in hematopoiesis. Kit ligand is a pleiotropic cytokine, which is essential for vertebrate erythropoiesis; however, in zebrafish, no such role has been reported so far. To determine the function of zebrafish paralogs of Kit ligand (Kitlga and Kitlgb) in hematopoiesis, we performed in vivo and ex vivo gain- and loss-of-function experiments. Strikingly, we were the first to report the synergistic cooperation of zebrafish Kitlga with erythropoietin and dexamethasone, enabling the growth of kidney marrow-derived suspension cells and providing optimal conditions for the expansion of adult erythroid progenitors. We assume that by using different cytokine combinations, optimal conditions for the growth of other hematopoietic cell types can be established, and therefore, this new approach now available for the...
Drug Information Centre service analysis IV. - drug interactions
Michálek, Georg ; Malá, Kateřina (advisor) ; Doseděl, Martin (referee)
Drug Information Centre service analysis IV. - drug interactions Author: Georg Michálek Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Drug information centre (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and University Hospital Hradec Králové was established in 1994. It provides drug information to healthcare professionals in the form of timely and accurate answers to drug-related enquiries, including drug interactions (DI). Aim: This study aimed to analyse enquiries related to DI processed by DIC from 2015 to 2020 and to solve three drug enquiries related to drug interactions. Methods: Quantitative and qualitative analysis of drug enquiries was carried out. Data was collected from individual enquiries related, but not limited to drug-drug, drug-herbal, and drug-disease interactions. The quantitative analysis based on descriptive statistical methods was performed on two levels: enquiry level and drug interaction level. On the enquiry level, ATC codes found in the enquiries were analysed and on the drug interaction level various parameters assigned to each DI were analysed, such as interacting components,...
IS in identification genetics
Dorčáková, Terézia ; Vaněk, Daniel (advisor) ; Formanová, Dominika (referee)
DNA analysis serves as a highly efficient identification tool when the biological material to be identified is heavily damaged or does not carry sufficient morphological characteristics. It is employed for human, but also for non-human identification in numerous cases such as crime investigation and prevention, populational studies, kinship analysis, paternity testing, mass grave body recognition or endangered species rescue. For successful identification, it is necessary to collect and maintain DNA profile databases. Such databases hold records of people involved in criminal activity or sequences from non-human sources. This work intends to review how identification and kinship analysis using genetic material works. Next, the most important databases collecting DNA profiles are summarised. Although the benefits of such databases are vast, there are many ethical concerns about misuse of such private information. For convenient database queries, a dedicated set of command line tools has been implemented by the author. These are used for an exemplary species identification of an unknown sequence.
Creation and analysis of in-house database of pyrazine derivatives with potential antimicrobial activity
Kebakuile, Legae Gomolemo Boemo ; Zitko, Jan (advisor) ; Kučerová, Marta (referee)
In the early phases of drug design and development, scientists must overcome many challenges involved in identifying potential drug-like or lead-like compounds. This has led to the need of creating large sets of chemical data which will aid in improving the identification of pharmacophores and active compounds. Various scientific fields especially pharmacology, medicinal chemistry and biochemistry have begun to employ the use of computer sciences to aid in the screening for potential leads with more specificity with regards to drug-like compounds' or substances' bioactivity. The emphasis of this project was to create a database containing a collection of pyrazine compounds synthesized overtime in the Faculty of Pharmacy (Charles University, Hradec Kralove) with the aim of having anti-mycobacterium (and possible antibacterial and antifungal) activity, and further utilize this database to predict certain pharmacokinetic and bioavailability properties. This project seeks to demonstrate how certain molecular descriptors can be used as reliable chemoinformation to determine the likeliness or possibility of developing a lead-like or drug-like compound by utilizing computer software. An in-house database of 623 compounds saved in SMILES format was created and used in demonstrating quantitative...
Service Design
Fišerová, Barbora ; Dědic, Filip (referee) ; Kubíková, Zuzana (advisor)
The diploma thesis describes the design of your own web application within the long-term collaborative project co.llaborate.online. In a small team, we reflect on our own workflow and designer work. Currently, the common goal is the design and development of MVP for processing text, images and other graphic material into any graphic output - graphic editor co.design. As part of the project, we have also focused for a long time on the concept of compatible MVPs for text editing or data management and user research. The starting point of co.llaborate.online is the principle of DRY (Don't repeat yourself) and the principles of web technologies. We test how certain workflows can be automated and facilitate the collaboration of designers, text authors, editors, proofreaders, etc., or emancipate users from unnecessary activities.
Complex On-Line Training Diary
Kamenský, Zdeněk ; Hynek, Jiří (referee) ; Bartík, Vladimír (advisor)
Design and implementation of online training diary for athletes is the main goal of this thesis. At the beginning, it was necessary to explain some of key words, related to the thesis topic. One of the most important things is data mining and its usability for sports data analysis. After that, existing solutions of sport applications were analyzed and also it was obligatory to analyze potential users requirements. Application design, implementation and testing were the next steps. Some of data mining methods were used for analysis of sports data intended for individual athletes and their coaches.
Smart power socket for charging electrical appliances in public areas
Chalupa, Tomáš ; Marada, Tomáš (referee) ; Zuth, Daniel (advisor)
This bachelor thesis is primarily focused on design and construction of a prototype smart power socket that will be used to charge electrical appliances in public areas. It provides user authentication based on an attached RFID element and monitoring of the charging progress. For this, it uses communication with an external cloud database. The actual construction of the prototype has been divided into three main parts in this thesis, control, electrical and mechanical. The introduction is also complemented by a research section dealing with microcontrollers, cloud systems and RFID technology.
Data Backup and Data Storages
Chytková, Markéta ; Kindlová, Dita (referee) ; Kříž, Jiří (advisor)
This bachelor thesis focuses on the problem of data backup in the company FOUL s.r.o., which offers football items. Bachelor thesis consists of three main parts, which are the theoretical basis, the analysis of the current state and the solution design. The output of this thesis is the design of a more efficient solution for data backup.
Database Design for a Selected Company
Bartoš, Jan ; Kříž, Jiří (referee) ; Luhan, Jan (advisor)
The aim of this thesis is to design a database for a selected company, which concerns the creation of production labels. Within this thesis I am going to concentrate on designing the structure of the database and its implementation. The database will be implemented on the Microsoft SQL Server platform using the tools of Microsoft Management Studio.
Database Design for a Selected Company
Kocman, David ; Neuwirth, Bernard (referee) ; Luhan, Jan (advisor)
This bachelor thesis contains a database design for a logging system in a selected company. The proposal itself is based on theoretical background, performed analyzes internal and external environment of the company and internal processes. The resulting design is a database solution containing functionalities that make it easier working with a database, securing a database and supporting managerial planning in the company.

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