National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Proteasomes and DNA virus infection
Vinšová, Barbora ; Drda Morávková, Alena (advisor) ; Motlová, Lucia (referee)
The development of virus infection depends on virus - host interactions. Millions of years of ongoing virus - host coevolution led to formation of many antiviral defense mechanisms as same as virus evasion strategies. Viruses have learned to intervene in the various cellular processes, modify it and take advantage of particular cellular components. One of those cellular components widely utilised by viruses is the ubiquitin-proteasome system. Proteasomes are multisubunit protein structures that under normal conditions provide degradation of damaged, missfolded or redundant cellular proteins. With their function proteasomes contribute to regulation of various cellular processes and maintain balance of proteins ratio. Viruses utilise those structures for protein degradation in order to evade host immunity system and deregulate cell cycle, to entry and unpacking of virions or in order to favor virus replication. This thesis is conceived to briefly summarize interactions of cellular ubiquitin-proteasome system and DNA viruses.

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