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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Late Steps in the cytosolic Iron-Sulfur Cluster Assembly in Trypanosoma brucei
 HAINDRICH, Alexander Christoph
The aim of this thesis was to investigate genes involved in the late steps of the Cytosolic Iron sulfur cluster Assembly (CIA) pathway in procyclic T. brucei, to determine their cellular localization and find their possible interaction partners and substrates.
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Erv1 associated mitochondrial import-export pathway and the cytosolic iron-sulfur protein assembly machinery in Trypanosoma brucei
 BASU, Somsuvro
This thesis highlights a divergent mitochondrial intermembrane assembly pathway in the parasitic protist Trypanosoma brucei. A comparative genomic study reveals the connection of Erv1 with the cytosolic iron-sulfur protein assembly (CIA) pathway in trypanosomatids. Further, the CIA machinery of T. brucei has been described using RNAi interference and other biochemical and complementation assays. Finally, part of the divergent CIA machinery has been identified in the human intestinal pathogen Giardia intestinalis by means of complementation assays in T. brucei.
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