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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
IL-15/IL-15Rα complexes as IL-15 superagonist
 Honzírková, Lucie ; Kovář, Marek (advisor) ; Javorková, Eliška (referee)
Interleukin 15 binds to its hight-afinity receptor IL-15Rα and forms stable IL-15/IL-15Rα complexes. IL-15Rα presents IL-15 in trans to target CD122/CD132 cells, where initiates signal transduction. Interleukin 15 has important role in immune system as it - regulates the homeostatic proliferation of memory CD8+ T cells and it is an essential for function, development and homeostasis of NK and NKT cells. Cell surface-expressed IL-15/IL15Rα complexes can be completely substituted by soluble recombinant IL-15/IL-15Rα-Fc complexes, which have substantially higher biological activity in composition to free IL-15 and behave as IL-15 superagonist. Il-15/IL-15Rα-Fc complexes are thus promising tool for some clinical use, i.e. cancer immune therapy, treatment of HIV or improvement of vaccination.
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