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Analysis of walking as energy source for biomedical applications
Cieslar, Filip ; Kovář, Jiří (referee) ; Hadaš, Zdeněk (advisor)
This paper deals with measurements and statistical processing of the acceleration data measured in the area of the human head. Types, principles of biomedical applications are shown, and problems pointed to its power supply. There are efforts to earn energy from surroundings of devices and extend its lifespan. Kinetic energy harvesters require such levels of acceleration for their excitation, that could possibly be obtained from human movements. 30 different people with different characteristics were thus measured during walking in order to find the common frequencies and relevant magnitudes created through vibrations during walking. Energy efficiency is evaluated using generator and use of this source to supply biomedical devices.
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Targeted biocompatible nanoparticles for therapy and cancer diagnostics.
Neburková, Jitka ; Cígler, Petr (advisor) ; Benson, Veronika (referee) ; Schirhagl, Romana (referee)
Nanoparticles (NPs) have considerable potential in targeted medicine. NPs can merge various functions and serve as labels for imaging or as nanocarriers in therapy. Modification of NPs with targeting ligands can lead to highly specific interactions with targeted cancer cells. However, the efficacy of targeting depends on the ratio between specific and non-specific interactions of a NP with the cell. Non-specific interactions of NPs are unrelated to targeted receptors and need to be eliminated in order to decrease background noise during imaging and adverse effect of drugs on healthy tissues. In this thesis, surface modifications of NPs were explored mainly on biocompatible carbon NPs called nanodiamonds (NDs), which have exceptional fluorescent properties such as long fluorescence lifetime, no photobleaching and photoblinking and sensitivity of their fluorescence to electric and magnetic field. Main issues addressed in this thesis are low colloidal stability of NDs in buffers and media, their non-specific interactions with proteins and cells and limited approaches for ND surface modifications. These issues were solved by coating NDs with a layer of biocompatible, hydrophilic, and electroneutral poly(ethylene glycol) or poly[N-(2- hydroxypropyl) methacrylamide] polymers. Optimized polymer coating...
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Targeted biocompatible nanoparticles for therapy and cancer diagnostics.
Neburková, Jitka
Nanoparticles (NPs) have considerable potential in targeted medicine. NPs can merge various functions and serve as labels for imaging or as nanocarriers in therapy. Modification of NPs with targeting ligands can lead to highly specific interactions with targeted cancer cells. However, the efficacy of targeting depends on the ratio between specific and non-specific interactions of a NP with the cell. Non-specific interactions of NPs are unrelated to targeted receptors and need to be eliminated in order to decrease background noise during imaging and adverse effect of drugs on healthy tissues. In this thesis, surface modifications of NPs were explored mainly on biocompatible carbon NPs called nanodiamonds (NDs), which have exceptional fluorescent properties such as long fluorescence lifetime, no photobleaching and photoblinking and sensitivity of their fluorescence to electric and magnetic field. Main issues addressed in this thesis are low colloidal stability of NDs in buffers and media, their non-specific interactions with proteins and cells and limited approaches for ND surface modifications. These issues were solved by coating NDs with a layer of biocompatible, hydrophilic, and electroneutral poly(ethylene glycol) or poly[N-(2- hydroxypropyl) methacrylamide] polymers. Optimized polymer coating...
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|
Analysis of walking as energy source for biomedical applications
Cieslar, Filip ; Kovář, Jiří (referee) ; Hadaš, Zdeněk (advisor)
This paper deals with measurements and statistical processing of the acceleration data measured in the area of the human head. Types, principles of biomedical applications are shown, and problems pointed to its power supply. There are efforts to earn energy from surroundings of devices and extend its lifespan. Kinetic energy harvesters require such levels of acceleration for their excitation, that could possibly be obtained from human movements. 30 different people with different characteristics were thus measured during walking in order to find the common frequencies and relevant magnitudes created through vibrations during walking. Energy efficiency is evaluated using generator and use of this source to supply biomedical devices.
|
|
Targeted biocompatible nanoparticles for therapy and cancer diagnostics.
Neburková, Jitka
Nanoparticles (NPs) have considerable potential in targeted medicine. NPs can merge various functions and serve as labels for imaging or as nanocarriers in therapy. Modification of NPs with targeting ligands can lead to highly specific interactions with targeted cancer cells. However, the efficacy of targeting depends on the ratio between specific and non-specific interactions of a NP with the cell. Non-specific interactions of NPs are unrelated to targeted receptors and need to be eliminated in order to decrease background noise during imaging and adverse effect of drugs on healthy tissues. In this thesis, surface modifications of NPs were explored mainly on biocompatible carbon NPs called nanodiamonds (NDs), which have exceptional fluorescent properties such as long fluorescence lifetime, no photobleaching and photoblinking and sensitivity of their fluorescence to electric and magnetic field. Main issues addressed in this thesis are low colloidal stability of NDs in buffers and media, their non-specific interactions with proteins and cells and limited approaches for ND surface modifications. These issues were solved by coating NDs with a layer of biocompatible, hydrophilic, and electroneutral poly(ethylene glycol) or poly[N-(2- hydroxypropyl) methacrylamide] polymers. Optimized polymer coating...
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|
Targeted biocompatible nanoparticles for therapy and cancer diagnostics.
Neburková, Jitka ; Cígler, Petr (advisor) ; Benson, Veronika (referee) ; Schirhagl, Romana (referee)
Nanoparticles (NPs) have considerable potential in targeted medicine. NPs can merge various functions and serve as labels for imaging or as nanocarriers in therapy. Modification of NPs with targeting ligands can lead to highly specific interactions with targeted cancer cells. However, the efficacy of targeting depends on the ratio between specific and non-specific interactions of a NP with the cell. Non-specific interactions of NPs are unrelated to targeted receptors and need to be eliminated in order to decrease background noise during imaging and adverse effect of drugs on healthy tissues. In this thesis, surface modifications of NPs were explored mainly on biocompatible carbon NPs called nanodiamonds (NDs), which have exceptional fluorescent properties such as long fluorescence lifetime, no photobleaching and photoblinking and sensitivity of their fluorescence to electric and magnetic field. Main issues addressed in this thesis are low colloidal stability of NDs in buffers and media, their non-specific interactions with proteins and cells and limited approaches for ND surface modifications. These issues were solved by coating NDs with a layer of biocompatible, hydrophilic, and electroneutral poly(ethylene glycol) or poly[N-(2- hydroxypropyl) methacrylamide] polymers. Optimized polymer coating...
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