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Issues of atopic dermatitis in context of nutrition
HAVLOVÁ, Ivona
The topic of my bachelor's thesis is "Issues of atopic dermatitis in context of nutrition." Atopic dermatitis is a type of skin inflammation in moist areas (back of the knee, inner elbow, groin). Skin health is affected by factors including the weather, textile and diet. Data were gathered using a qualitative research and snowball sampling. A survey was conducted among nine respondents, each providing information on the food they ate for a week. The goal was to map atopic dermatitis in the context of nutrition. The practical part of the thesis focused on what foods seem to be the most problematic for respondents. The survey showed these include citrus fruit, sweets, highly processed foods and especially alcohol. Respondents said that wine was the most problematic among alcoholic beverages. A few respondents mentioned nuts, soya and dairy. Seasons also have an impact on the atopic dermatitis incidence, with winter posing the biggest problem and summer following. A link between atopic dermatitis and the weather has not been properly studied and cannot be confirmed. The food analysis was recorded in the Nutriservis app. Data were entered into an Excel table that includes energy and macronutrient values of individual meals. The analysis shows that most respondents eat bread/rolls with ham or cheese, or cereal for breakfast. Snacks are similar but smaller than breakfasts. Lunches and dinners are often home-made meals consisting of good polysaccharides (rice, pasta, potatoes), meat (mostly chicken) and vegetables. The analysis reveals often unbalanced energy intake over the week, mostly because of alcohol consumption. Most respondents eat enough fruit and vegetables.
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Effects of the Interferon regulatory factor 3 on immune responses to vaccinia virus in the atopic organism
Pilná, Hana ; Mělková, Zora (advisor) ; Drbal, Karel (referee)
Vaccinia virus (VACV) is an enveloped DNA virus, member of the Orthopoxviridae genus. VACV genome size is about 200 kbp. This huge genome capacity allows VACV to encode a set of factors that are non-essential for virus replication and spread in vitro. While these factors are needed for interfering with host immune responses, VACV remains strongly immunogenic. Cell-mediated and humoral immune responses in atopic disorders are deregulated to a certain extent, leading to complications in case of infection or vaccination with vaccines based on replicating viruses, such as eczema vaccinatum caused by VACV. VACV effects on immune responses consist among others in the inhibition of expression of type I interferon (IFN) at various levels - for example in a specific inhibition of phosphorylation of the interferon regulatory factor-3 (IRF-3) via inhibition of the activity of TANK-binding kinase 1 (TBK 1) that normally phosphorylates IRF-3. Phosphorylation allows IRF-3 to translocate into the nucleus where it initiates transcription of IFNβ followed by induction of expression of IFN and interferon stimulated genes. Expression of these genes is shut down when IRF-3 activity is inhibited. To overcome this block, a recombinant VACV expressing murine IRF-3 under VACV p7.5 promotor (WR-IRF3) was generated....
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Allergic diseases in relation to lifestyle risk factors by children in younger school age in the Region of Karlovy Vary
RYBOVÁ, Eliška
As the subject of my Bachelor{\crq}s work I choose "Allergic diseases in relation to risk factors of the life style of children of younger school age in the region Karlovy Vary" because I think that allergies represent a topical problem which due to its nature affects not only children but also our whole society. The aim of the work is to find out how the selected life style factors share in the occurrence of allergies of children of younger school age in the region Karlovy Vary. The work comprises a theoretical and a practical part. The theoretical part comprises comprehensive theoretical knowledge from the field of allergology that should outline the conditions for the development of allergies, the occurrence of allergies in course of the life, the most common allergic diseases and their subsequent diagnosis and treatment. The practical part is devoted to the realised research which was carried out from November 2009 to January 2010 in regional towns and municipalities of the region Karlovy Vary. The research was performed using the form of the quantitative research, the inquiry method and as the data collection technique was used the anonymous questionnaire. The research file included children of younger school age from 4th and 5l classes of primary schools. As the results of the research show, the children who live in big cities have almost comparable occurrence of allergies as the children from small villages. The results also show that the children who are the most exposed to a smoky environment at home have also the biggest occurrence of allergies in contrast to the children who are not exposed to a tobacco environment at all and for whom predominate an absence of allergies. The investigation into whether the lack of microbes influences the occurrence of children allergies demonstrated in case of using disinfecting agents that shorter periods of their usage have an influence on the occurrence of allergies and to the contrary. The research also shows that elements which share in the character of housing have in case of allergies quite individual displays and therefore can not be denominated as significant factors in general. The results of this research can bring useful information to children allergists as well as wide public when the acquired knowledge can increase the interest in these problems and therefore improve preventive and repressive measures in this field.
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