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National Repository of Grey Literature

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Attributes Calculating for Prediction of Effects of Mutation on Protein Function Matějíček, Jiří ; Burgetová, Ivana (referee) ; Jaša, Petr (advisor) This bachelor thesis deals with the bioinformatics techniques for the acquisition of attributes useful for prediction of mutation effects on the protein function. The work primarily aims to develop a user-friendly application for calculation of attributes of mutations from the protein sequence and structure. The developed application serves for integration of specialized tools such as FoldX. The standardized interface enables to implement additional computational tools and collect a diverse set of attributes from different sources. These attribute sets can then serve as an input for different prediction methods and help to improve predictions of mutation effects. Detailed record

Attributes Calculating for Prediction of Effects of Mutation on Protein Function Matějíček, Jiří ; Burgetová, Ivana (referee) ; Jaša, Petr (advisor) This bachelor thesis deals with the bioinformatics techniques for the acquisition of attributes useful for prediction of mutation effects on the protein function. The work primarily aims to develop a user-friendly application for calculation of attributes of mutations from the protein sequence and structure. The developed application serves for integration of specialized tools such as FoldX. The standardized interface enables to implement additional computational tools and collect a diverse set of attributes from different sources. These attribute sets can then serve as an input for different prediction methods and help to improve predictions of mutation effects. Detailed record

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