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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Detekce polymorfismu v genu MDR1 u ovčáckých a honáckých psů
 Staroveská, Marieta
This thesis is focused on polymorphism of MDR1 gene and related drug resistance. Resistance is caused by deletion of four nucleotids, that resulting in a frame shift and synthesis of nonfunctional transport of P-glycoprotein. The text describes a polymorphism of MDR1 (ABCB1) gene, which results in reduced resistance to drugs belonging to the group of macrocyclic lactones. It also describes inheritance of this phenomenon and it deals with the detection of mutation using PCR (polymerase chain reaction) and by fragmentation analyses. A review of literature study is a form of research solely from scientific publications. 128 dogs were included into the own analysis. The results confirmed that Collies had the highest presence of deletions (29,73 %) with a high number of carriers in the study population of dogs (54,05 %). The percentage of affected individuals in the breed of Australian Shepherd and Sheltie was significantly lower (7,32 % and 6 %), but the percentage of carriers were also high in both Australian Shepherds (34,14 %) and the breed Sheltie (48 %).
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Mutace genu v MDR1 u psů ve vztahu k citlivosti na léčiva
 Patermannová, Veronika
This work deals with the multidrug resistance gene (MDR1), its structure, function, localization on dog's genome and especially its dysfunction in case of mutation. Work gives information about heredity of mutated alleles MDR1 gene, detection mutation using polymerase chain reaction (PCR). Information are written as a literature review and were drawn from scholarly articles. On base these articles was created summary of frequency all genotypes MDR1 gene in dogs in Czech Republic and foreign countries.
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