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The activity ratio of 30. minute/2.-3. minute in the Dynamic renal scintigraphy
KUKAČKOVÁ, Jana
The objective of the present Bachelor thesis is to determine normal values of the ratio of activity in the Region of Interest (ROI) of a healthy kidney in the 30th minute of the examination compared to the 2nd - 3 rd minutes in patients up to 18 years of age at the Nuclear Medicine Department in České Budějovice. For the purposes of comparison, values of the ratio of activity in ROI of the kidney in the 30th minute are compared with the peak in the same patients. Dynamic kidney scintigraphy with 99mTc-MAG3, generally modified by a furosemide test, is carried out in case of child patients with respect to whom simple dilatation of the pelvicalyceal system must be distinguished from obstruction. A set of 35 patients at the age of 0-18 was selected for the purposes of statistical processing in the period from 01 January 2018 to 13 November 2018, whereupon these patients underwent dynamic kidney scintigraphy with 99mTc-MAG3. As a result, 47 usable renal units were obtained. Renal units with pathological findings were removed from the set. In these renal units, the ratio of activity 30th min./3rd min. and the ratio 30th min./peak were observed. For comparison, the total of 4 selective statistical sets (VSS) were formed - a group of patients at the age of 0-18 and a more restricted group of patients at the age of 0-10 years for both ratios of activity. The collected data were subsequently used for parametric testing. The contribution of this thesis consists in the determination of normal values of the ratio of activity 30th minute/2nd - 3 rd minutes, which will be useful in differentiating mild dilatation from other pathological conditions (obstruction, reductions in function, etc.) in patients examined by dynamic kidney scintigraphy at the Nuclear Medicine Department in České Budějovice. The elementary static processing implies that normal values of the ratio of activity 30th min./3rd min. oscillate in the interval of values (0.058; 0.238) in patients up to 18 years of age, and in the interval (0,05; 0.27) in patients up to 10 years of age. For the sake of comparison, values of the ratio of activity 30th min./peak oscillate in the interval of values (0,026; 0.246) in patients up to 18 years of age, and in the interval (0.04; 0.26) in case of patients up to 10 years of age. It may be stated that values of ratios of activity 30th min./3rd min. and 30th min./peak are approximately comparable. Based on the applied double-selection t-test, the zero hypothesis was adopted, meaning that the selective statistical sets originate from the same basic statistical set on the given significance level.
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