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Polyethylene wear particles around joint replacements - their properties, distribution and possible mechanism of their adverse biological effects
Zolotarevová, Eva ; Gallo, Jiří (advisor) ; Rauch, Pavel (referee) ; Horák, Zdeněk (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF SCIENCE DEPARTMENT OF BIOCHEMISTRY PRAGUE 2010 Supervisor: Doc. MUDr. Jiří Gallo, PhD. Supervisor-consultant: Prof. RNDr. Gustav Entlicher, CSc. Eva Zolotarevová Summary of PhD Thesis POLYETHYLENE WEAR PARTICLES AROUND TOTAL JOINT REPLACEMENTS - THEIR PROPERTIES, DISTRIBUTION AND POSSIBLE MECHANISM OF THEIR ADVERSE BIOLOGICAL EFFECTS PRAGUE 2010 The research project was supported by the Grant project of National research program II. (no. 2B06096) of the Czech Ministry of Education, Youth and Sports named "Observation and minimization of UHMWPE wear in joint replacements". Front-page picture: Polyethylene wear particle isolated from granuloma tissue surrounding total hip replacement; Electron microscope microphotograph; particle size app. 90 x 80 µm; retouched Eva Zolotarevová Introduction Introduction For many people all over the world a replacement with an implant of irreversibly damaged joint is often the only way how to come back to normal life without pain and mobility limitation. Nowadays, greater and greater requirements are asked of quality of all replacement components, especially in terms of quality of used materials. Biomechanical properties of hip and knee replacements have been already solved. The most often used materials for manufacturing joint...
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Polyethylene wear particles around joint replacements - their properties, distribution and possible mechanism of their adverse biological effects
Zolotarevová, Eva
This PhD thesis in essence rounds off the range of queries asked several years ago when the task was set by Doc. RNDr. Zdenek Horak, PhD. The original isolation procedure for polyethylene wear particles, identification of some of their physico-chemical properties and manipulation accordingly has been successful in the process of this thesis accomplishment. It became possible to quantify the particles at relative as well as absolute scale. The thesis managed to disprove the published opinion that centrifugation can affect the morphology of isolated particles. The issue of distribution of polyethylene wear particles around hip endoprothesis has been solved at two levels: "macroscopically", the distribution of wear particles in zones around endoprosthesis was showed (this thesis does not include these data). Furthermore, at the "microscopic" level, the distribution of wear particles in granuloma tissue from the zones surrounding endoprostheses with most particles has been determined. The granuloma tissue formed in zones with most particles because of that. It was observed that the common term - osteoagressive granuloma - used by orthopedist is rather misguided. Granuloma is not aggressive to bone tissue. On the contrary, the granuloma formation reduces the effective amount of wear particles with...
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Polyethylene wear particles around joint replacements - their properties, distribution and possible mechanism of their adverse biological effects
Zolotarevová, Eva
This PhD thesis in essence rounds off the range of queries asked several years ago when the task was set by Doc. RNDr. Zdenek Horak, PhD. The original isolation procedure for polyethylene wear particles, identification of some of their physico-chemical properties and manipulation accordingly has been successful in the process of this thesis accomplishment. It became possible to quantify the particles at relative as well as absolute scale. The thesis managed to disprove the published opinion that centrifugation can affect the morphology of isolated particles. The issue of distribution of polyethylene wear particles around hip endoprothesis has been solved at two levels: "macroscopically", the distribution of wear particles in zones around endoprosthesis was showed (this thesis does not include these data). Furthermore, at the "microscopic" level, the distribution of wear particles in granuloma tissue from the zones surrounding endoprostheses with most particles has been determined. The granuloma tissue formed in zones with most particles because of that. It was observed that the common term - osteoagressive granuloma - used by orthopedist is rather misguided. Granuloma is not aggressive to bone tissue. On the contrary, the granuloma formation reduces the effective amount of wear particles with...
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Polyethylene wear particles around joint replacements - their properties, distribution and possible mechanism of their adverse biological effects
Zolotarevová, Eva ; Gallo, Jiří (advisor) ; Rauch, Pavel (referee) ; Horák, Zdeněk (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF SCIENCE DEPARTMENT OF BIOCHEMISTRY PRAGUE 2010 Supervisor: Doc. MUDr. Jiří Gallo, PhD. Supervisor-consultant: Prof. RNDr. Gustav Entlicher, CSc. Eva Zolotarevová Summary of PhD Thesis POLYETHYLENE WEAR PARTICLES AROUND TOTAL JOINT REPLACEMENTS - THEIR PROPERTIES, DISTRIBUTION AND POSSIBLE MECHANISM OF THEIR ADVERSE BIOLOGICAL EFFECTS PRAGUE 2010 The research project was supported by the Grant project of National research program II. (no. 2B06096) of the Czech Ministry of Education, Youth and Sports named "Observation and minimization of UHMWPE wear in joint replacements". Front-page picture: Polyethylene wear particle isolated from granuloma tissue surrounding total hip replacement; Electron microscope microphotograph; particle size app. 90 x 80 µm; retouched Eva Zolotarevová Introduction Introduction For many people all over the world a replacement with an implant of irreversibly damaged joint is often the only way how to come back to normal life without pain and mobility limitation. Nowadays, greater and greater requirements are asked of quality of all replacement components, especially in terms of quality of used materials. Biomechanical properties of hip and knee replacements have been already solved. The most often used materials for manufacturing joint...
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