National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Rich Information Optical Biosensor Based on Surface Plasmon Resonance
Dostálek, Jakub ; Homola, Jiří (advisor) ; Richter, Ivan (referee) ; Vrbová, Miroslava (referee)
In the presented thesis, new optical biosensor platform for high-throughput label-free monitoring of biomolecular interactions is reported. This biosensor platform is based on a spectroscopy of surface plasmons on an array of miniature diffraction gratings. Each miniature grating serves as an independent sensing channel and allows for monitoring of optical density changes induced by biomolecular interactions on the grating surface. The presented platform has a potential for monitoring of hundreds of interactions on a single sensor chip. The presented research include theoretical study of surface plasmon resonance on metallic diffraction gratings and the analysis of diffraction grating-based SPR biosensor. In the experimental work, preparation, replication and characterization of diffraction gratings is carried out. A prototype SPR sensor device including an SPR sensor chip with a twodimensional array of sensing channels, fluidic system and SPR chip reader is developed and its main performance characteristics are determined.
Molekulární podmíněnost rezistence lnu vůči těžkým kovům a možnost jejího ovlivnění transgenozí
Vrbová, Miroslava
This work is focused on the molecular conditionality of flax resistance to heavy metals. Attention was therefore devoted to the identification of proteins whose role in stress response to heavy metals have not been discovered yet in flax. Two contrasting flax varieties displayed differences in steady state levels of short thiol peptides (GSH and PC) and heavy-metal binding proteins (ferritin and lipocalin) which can detoxify cadmium via chelation. These results are the first published analysis of the proteomic response to cadmium exposure in commercially important annual crop with potential use in phytoremediation. Another of the objectives was to verify the possibilities of influencing the flax resistance to heavy metal using transgenosis. There were obtained a multiplied flax plants, in which the presence of a transgene was verified, and these lines were tested for tolerance and accumulation of cadmium in both in vitro and in the field conditions.

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2 Vrbová, M.
4 Vrbová, Marie
2 Vrbová, Markéta
26 Vrbová, Martina
4 Vrbová, Michaela
1 Vrbová, Monika
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