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Current approaches in the development of vaccines against infectious viral diseases
Vargová, Soňa ; Malý, Petr (advisor) ; Osička, Radim (referee)
Vaccination remains one of the most successful biomedical interventions for preventing viral diseases. While early vaccines were developed by attenuating the infectious agent in cell cultures or by inactivation, new delivery platforms are on the rise thanks to the advent of genetic engineering. The COVID-19 pandemic stimulated the rapid adoption and a massive deployment of these platforms. Viral vector vaccines elicit antigen expression within cells and induce a robust cytotoxic T cell response, unlike protein subunit vaccines conferring mainly humoral immunity. mRNA vaccines also deliver the antigen inside the cells while offering more manageable and faster manufacturing possibilities. Unlike DNA-based vaccines, mRNA does not enter the nucleus, and thus, the probability of disrupting gene expression in the recipient cell is diminished. This thesis aims to offer an overview of current approaches in vaccinology and discuss the various platforms in use. The thesis will also present recent advances in the development of prophylactic vaccines against infections with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) and also will focus on a recently proposed strategy for vaccine development based on non-cognate ligands mimicking epitopes recognised by broadly neutralising antibodies...
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The Influence of Chinese Investments on Relations between ECOWAS and EU
Vargová, Soňa ; Cihelková, Eva (advisor) ; Bič, Josef (referee)
This thesis is devoted to analyzing the impact of Chinese investments in the region of West Africa on relations between ECOWAS and European Union. The first chapter characterizes Community of West African States - geographically, demographically and especially in the area of macroeconomics. Following chapter focuses itself on relations of PRC and ECOWAS. Particular attention is paid to foreign direct investments, which is China realizing in the area. ECOWAS relations with the European Union and the changes that have occurred in recent years are described in the third chapter of the thesis. A separate section describes the Economic Partnership Agreements. The conclusion represents the analysis of changes in trade relations between ECOWAS and the EU.
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The Position of the grouping ECOWAS in International Trade
Vargová, Soňa ; Černá, Iveta (advisor) ; Taušer, Josef (referee)
ECOWAS is the integration grouping of 15 West African countries. The first chapter deals with the history, geography, demography and economic situation of the grouping. The main objective of this bachelor thesis was to analyze position of West Africa in international trade and identify the expected development in the future. Last chapter is devoted to 4 representative Member States of ECOWAS - Nigeria, Ghana, Ivory Coast and Liberia.
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