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Assessment of quality of life of patients with epilepsy using QOLIE-31.
Zývalová, Aneta ; Vlček, Jiří (advisor) ; Kubová, Hana (referee)
1 UNIVERZITA KARLOVA V PRAZE FARMACEUTICKÁ FAKULTA V HRADCI KRÁLOVÉ Katedra sociální a klinické farmacie Hodnocení kvality života pacientů s epilepsií pomocí dotazníku QOLIE-31 Assessment of quality of life of patients with epilepsy using QOLIE-31 Diplomová práce Vedoucí diplomové práce: Doc. RNDr. Jiří Vlček, CSc. HRADEC KRÁLOVÉ 2007 Aneta Zývalová 2 Prohlašuji, že jsem diplomovou práci vypracovala samostatně, s použitím uvedené literatury. 3 Děkuji Mgr. Evě Tlusté za obětavou pomoc při psaní diplomové práce. Její odborné zkušenosti, praktické připomínky a vstřícný přístup mi byly velmi nápomocné. Dále bych ráda poděkovala doc. RNDr. Jiřímu Vlčkovi, CSc. za odborné vedení. V neposlední řadě bych ráda poděkovala celé své rodině, která mi byla oporou během celého studia. 4 Obsah 1. ÚVOD A CÍL PRÁCE ....................................................7 2. REŠERŠNÍ ČÁST.........................................................8 2.1. EPILEPSIE .............................................................................. 8 2.1.1. Definice ................................................................................ 8 2.1.2. Historie ................................................................................. 8 2.1.3. Epidemiologie...
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ASSESSMENT OF POTENTIAL DRUG INTERACTIONS IN TWO INPATIENT WARDS IN UNIVERSITY HOSPITAL IN HRADEC KRÁLOVÉ
Maříková, Martina ; Vlček, Jiří (advisor) ; Macek, Karel (referee)
! ASSESSMENT OF POTENTIAL DRUG INTERACTIONS IN TWO INPATIENT WARDS IN UNIVERSITY HOSPITAL IN HRADEC KRÁLOVÉ Author: Maříková M.* Tutor: Vlček J.** *Clinical Pharmacy Department University Hospital Hradec Králové **Social and Clinical Pharmacy Department, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, The Czech Republic Keywords: drug interactions, clinical pharmacist, drug-related problems, geriatric patients, intensive care Background: Medicine and pharmacy are two different but related disciplines that complement, overlap and need each other. The first work, which has looked at medication errors was published in the nineties of the 20th century by the American Institute of Medicine "To Err is Human: Building a Safer Health System's" issued in November 1999. The report is based on analysis of several different studies, concluding that 44.000 to 98.000 people die each year because of preventable drug errors. In comparison, fewer than 50.000 people died from Alzheimer's disease and 17.000 died of illicit drug use in the same year. Each administration of the drug to the patient is a kind of experiment, which rely on available population data of pharmacokinetic and pharmacodynamic properties of drugs. The same situation is in a topic of drug interactions. Number of drugs in use...
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Patient Perspective of Medication Information Desired
Kalaitzidis, Panagiotis ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Title: Patient perspective of medication information desired Student: Kalaitzidis Panagiotis Tutor: Jiri Vlcek Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Even from the decade of 1970, patients wanted more information about drugs and did not want to be so depended on the information the physician provided them. Today patients are more than ever informed about their disease and the available and appropriate treatment, due to the high volume of information that can be acquired through the Internet. The traditional role of pharmacists was the provision of medicines to the population. However, nowadays, this role has been changed so as to include other tasks, such as management of prescribed medicines, and promotion of health, since pharmacists can serve as a source of expertise knowledge to the customers. Due to the fact that there is no relevant research for the case of Greek patients, this pilot research could help to fill this gap, by trying to find out what kind of information patients want to know about medicines in several pharmacies in Greece. Aim: The aim of this research is to examine what kind of information patients want related to medicines. More precisely, this research will try to identify the type of...
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The analysis of antibiotics expositio in inpatients after transplantion of stem cells
Dobrovolný, Lukáš ; Vlček, Jiří (advisor) ; Matoulková, Petra (referee)
UNIVERZITA KARLOVA V PRAZE FARMACEUTICKÁ FAKULTA V HRADCI KRÁLOVÉ KATEDRA SOCIÁLNÍ A KLINICKÉ FARMACIE Abstract of diploma thesis Lukáš Dobrovolný 2008 The analysis of exposition of antibacterial drugs in patiens after stem cell transplantation The thesis focused on gaining the resistence level data connected with six most common microbial organisms isolated in Czech republic even through whole Europe. The uniqueness of the study flows from the characterisitics of analysed patients'group with sorted serious blood malignities requiring bone marrow transplantation. Moreover the thesis' aim is to judge, whether the correctness, accuracy, frequency of the administration and the sufficiency of the used daily dosages of the antimicrobial drugs in the cliníc was in order. The script also addresses to the field of combined antimicrobial treatment. It also scans, which drugs are administered in the hospitál department and under what circumstances and those empirical data compares with the guidelines. This diploma work observes as well the popularity of administered medicaments and examines their usage during two investigated years. The present day state referring to multi or poly rezistent germs including the mechanisms of the selection of these perilous clones is analysed in the theoretical part. That thesis...
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Analysis of treatment of patients with epilepsy dispenzarized in University Thomayer's Hospital in Prague.
Frýdlová, Dana ; Vlček, Jiří (advisor) ; Kubová, Hana (referee)
Analysis of treatment of patients with epilepsy dispenzarized in University Thomayer's Hospital in Prague Student: Frýdlová D. Tutor: Vlček J., Tlustá E. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: Studies on antiepileptic drug utilization are important for evaluation of epilepsy treatment and risk of antiepileptic drugs (AEDs). Aim: To describe group of patients with epilepsy, AEDs utilization patterns and adverse drug reactions (ADRs) of AEDs. Methods: Data were retrieved from medical records in University Thomayer's Hospital in period 2005 - 2006. Epileptic outpatients (n = 97) aged over 16 years were considered for analysis. Results: The age ranged from 17 to 72 years (mean 55), 62 % were women. Partial seizures were diagnosed in 62 % of patients. 31 % of patients were more then 2 years without seizures, 39 % of patients had more then 12 seizures per year. More then half (65 %) of the patients were treated with polytherapy. Lamotrigin was the most commonly prescribed AED (20 %), followed by valproate (18 %) and carbamazepine (17 %). The most frequently prescribed AED in monotherapy was valproate, followed by lamotrigin, carbamazepine and levetiracetam. The ADRs were recorded in 41 patients. The most...
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Analysis of consumption of antibiotics in patients treated with dialysis
Ždímalová, Radka ; Vlček, Jiří (advisor) ; Matoulková, Petra (referee)
1. ABSTRACT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of social and clinical pharmacy Candidate: Ždímalová Radka Supervisor: Prof. RNDr. Jiří Vlček, CSc. Title of rigorous Thesis: Analysis of consumption of antibiotics in patients treated with dialysis Introduction and objective: This study observes consumption of antibiotics in patients treated with dialysis in The University Hospital of Hradec Králové in years 2006 and 2007. Pilot project investigate, which kind of antibiotics used dialyzed patients (DP) the most of all. Studies further compare information from two sets of DP from Czech Republic (Group I) and Lithuania (Group II) in specific aspects of antibiotic's consumption. Methodology: Retrospective analysis resulting from data evaluation from Nephris database of University Hospital of Hradec Králové by DP (2006&2007). Set of data of the Group II from Clinics of Kaunas Medical University - Lithuania was process by retrospective analysis too. GLMZ mode was used for statistical analysis. Results: Group I: from average number of 125 hospitalized patients were treated by antibiotics 71 (57%) patients. Both men and women have the same representation in the group, patients undergoing dialysis mostly in higher age, what has been discovered by mean age 66 years. From 71...
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Knowledge of patients with diabetes mellitus about hypoglycaemia.
Hromádková, Lucie ; Vlček, Jiří (advisor) ; Matoulková, Petra (referee)
Nowadays, diabetes mellitus belongs to wide-spread diseases. 4-7% of population suffer from diabetes in developed countries and the number is increasing. Education of patients with diabetes mellitus ensures effective treatment and it contributes to the delay of diabetic complications. Therapy itself without correct and effective patient education can hardly lead to successful treatment. One of the frequent diabetic complications is hypoglycaemia, which can be fatal due to patient ignorance. The aim of this pilot study was to evaluate the degree of patient knowledge about hypoglycaemia, to monitor its distribution among patients and to analyze its possible risk factors. Cross-sectional observational study was used for the analysis. Data were obtained from structured direct interviews carried out among diabetic patients. The study was performed in Faculty hospital in Hradec Králové. Submission of patients into the study was random. Patients with diabetes mellitus types 1. and 2. visiting the diabetologic centre in Faculty hospital in Hradec Králové were included. Information was gained from 100 patients (109 addressed (92 %)). The average age of respondents was 54 years and men prevailed (55 %). The number of diabetic patients of type 2 was two times higher than the number of diabetic patients of type...
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Analysis Of Prescribing Errors Identificated By Pharmacist During Provision Of Pharmaceutical Care
Kotalová, Petra ; Vlček, Jiří (advisor) ; Macek, Karel (referee)
ANALYSIS OF PRESCRIBING ERRORS IDENTIFICATED BY PHARMACIST DURING PROVISION OF PHARMACEUTICAL CARE Autor: Kotalová P.* Tutor: Vlček J.** * Pharmacy Repharm, Ostrava, Czech Republic, ** Dept. of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic. Background: Medication errors or drug related problems (DRPs) have a negative impact on the whole process of health care and are significant health risk for a patient. Aim of study: The aim of this study was to describe and evaluate the role of pharmacist in identification and solution of prescribing errors. And to discuss the possibilities of the further development of safe medication practices in the Czech republic. Methods: 33 pharmacists from community and hospital pharmacies participated in a study. Data were collected by web questionnaire for a period of 15 days. The following DRPs were collected: incorrect indication of drugs or contraindicated drugs, prescribing of drug for incorrect patient, wrongly prescribed name of drug, contraindications, duplications of therapy, potential drug interactions or problems with dosage (e.g. overdosing). The identified errors were classified and the clinical significance of the cases and accuracy of pharmacist's interventions were evaluated. Statistic...
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