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A study of the influence of co-processed dry binder type on the properties of oraly disintegrating tablets with the drugs ibuprofen and paracetamol.
Víšková, Michaela ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Consultant: Mgr. Thao Tranová Student: Michaela Víšková Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with the drugs ibuprofen and paracetamol. This thesis deals with the study of orally disintegrating tablets containing co-processed dry binders Ludiflash® , Prosolv® ODT G2 and Parteck® ODT with analgesics ibuprofen and paracetamol. The tablets also include magnesium stearate as a lubricant and sucralose as a sweetener at a concentration of 1%. The energy profile of the compression process, tablet tensile strength, friability, porosity, wetting time, water absorption ratio and disintegration time of the tablets are evaluated. Tableting material with Prosolv® ODT G2 shows the lowest value of pre-compression energy, drugs increase it. Furthermore, it shows the highest value of compression energy that drugs reduce. Prosolv® ODT G2 and Parteck® ODT placebo tablets have higher tensile strength than Ludiflash® placebo tablets. Drugs reduce tablet tensile strength, paracetamol more significantly. Placebo tablets meet the requirement for friability (up to 1 %), whereas in the case...
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Gambling in Juveniles
VÍŠKOVÁ, Michaela
I have chosen the topic of my bachelor paper ``Gambling in Juveniles{\crq}q because of its seriousness and topicality. The pathologic gambling has been more and more penetrating among juveniles to whom it causes, in the same way as in the adult population, more and more serious problems in the socio-economic sphere. This serious social pathologic phenomenon can be compared to drug addiction even though it does not damage human body in such fatal way. However, it affects the sphere of human psyche as well as the sphere of one{\crq}s social relations. And in the same way as drug addiction it has, in many cases, fatal impact on human life. My bachelor paper aims at finding out the extent and triggers of gambling in the population of high school juveniles in the area of Havlíčkův Brod. In the theoretic part of the paper specifics of gambling in children and juveniles are described as well as possible prevention of this phenomenon. Further diagnostic criteria of a pathologic gambler are described, the personality of a gambler is characterized, stages of development of pathologic gambling are defined and the corresponding legislature is dealt with. To fulfill the outlined goals, data were collected by means of the method of quantitative survey using anonymous questionnaires at six high school type schools (gymnasiums, professionally oriented high schools, craft oriented high schools). The questionnaires monitor students{\crq} experience with gambling machines and their reasons for gambling. The questionnaires further monitor students{\crq} awarness of the issue as well as prevention carried out at school they study at. On the basis of the survey I have checked three presumed hypotheses. Hypothesis 1: Students of craft oriented high schools yield more frequently to gambling than students of other high school types and gymnasiums. This hypothesis proved right. Hypothesis 2: Boys tend to yield to gambling more than girls. Also this hypothesis proved right. Hypothesis 3: Juveniles yield to gambling machines and to gambling more often under the influence of another person than from their own tending. This hypothesis proved wrong. The results of my bachelor paper can be used for the needs of further survey, for the needs of teaching and preventive measures at educational institutions and to increase the awareness concerning the gambling problematics in juveniles.
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Involuntary Client in Social Work
VÍŠKOVÁ, Michaela
The objective of my work is to survey what kinds of social work tools motivate, from the view of a social worker, an involuntary client to change his/her current situation and start working with a social worker. In the theoretical part of my diploma work I first deal with general topics, I focus on the typology of clients and relation and communication with clients. Within the section that is dedicated to the involuntary client solely I deal with the characteristics of such a client and ethical dilemmas in respect of the relation to this client. Furthermore, I present some recommendations for work with an involuntary client and I concentrate more on motivating the client. The chapter that deals with specific features of social work with addictive substances users, as one of the groups of involuntary clients, forms an extensive part of the theoretical part. In order to achieve the set objective, I have chosen a combination of quantitative and qualitative research. The data have been collected by means of anonymous questionnaires and non-standardized dialogues with 144 social workers in the Vysočina Region. Within the research I study the experience of social workers with work with involuntary clientele, further I focus on methods and techniques used at work with involuntary clients and on theoretical bases of this work as well. The survey also aims to determine the diversity in the approach of social workers in respect of voluntary and involuntary clientele. Following the evaluation of the survey outputs it can be said that a majority of social workers meet involuntary clients at their work. However, not all the workers consider the use of a specific approach to such clients important. A possible improvement in this respect may, in my opinion, be brought by educational courses that focus on the issues of involuntary clientele. Supervision plays an irreplaceable role here, too. The results of my diploma work may be used for the needs of further research, teaching and in order to enhance the knowledge of the issues of involuntary clientele.
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