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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Determining the compression behaviour of fillers and magnesium stearate
 Szwedová, Lenka ; Řehula, Milan (advisor) ; Špaček, Vladimír (referee)
1 Abstract The energy of tablets compaction is obtained from the force-distance record. The aim of this work was to determine accumulated energy in a tablets (plastic energy), to determine energy released from a tablet after compaction (elastic energy) and summation of these two energies. Mixtures of magnesium stearate 0%, 0,5% and 1% were prepared in a blending cube. The T1 - FRO 50 compacting machine was used for compacting tablets (weight of each tablets was 500 mg). Compacting forces were 5, 10 and 15 kN. In the first procedure the compaction was ceased after reaching the maximal compaction force, in the second procedure the upper punch was stopped when the maximal compaction force was reached and during 180 s dwell time of decreasing compacting force was recorded while the tablet height was kept constant. The results show that increasing concentration of lubricant leads to a decrease of accumalated energy in a tablet and on the contrary it leads to an increase of energy released from a tablet. The 180 s dwell time with a tablet height kept constant increases plastic energy because of forming more bonds. Microcrystalline cellulose is characterized by higher plastic and lower elastic energy than lactose monohydrate.
Detailed record
Determining the compression behaviour of fillers and magnesium stearate
 Szwedová, Lenka ; Řehula, Milan (advisor) ; Špaček, Vladimír (referee)
1 Abstract The energy of tablets compaction is obtained from the force-distance record. The aim of this work was to determine accumulated energy in a tablets (plastic energy), to determine energy released from a tablet after compaction (elastic energy) and summation of these two energies. Mixtures of magnesium stearate 0%, 0,5% and 1% were prepared in a blending cube. The T1 - FRO 50 compacting machine was used for compacting tablets (weight of each tablets was 500 mg). Compacting forces were 5, 10 and 15 kN. In the first procedure the compaction was ceased after reaching the maximal compaction force, in the second procedure the upper punch was stopped when the maximal compaction force was reached and during 180 s dwell time of decreasing compacting force was recorded while the tablet height was kept constant. The results show that increasing concentration of lubricant leads to a decrease of accumalated energy in a tablet and on the contrary it leads to an increase of energy released from a tablet. The 180 s dwell time with a tablet height kept constant increases plastic energy because of forming more bonds. Microcrystalline cellulose is characterized by higher plastic and lower elastic energy than lactose monohydrate.
Detailed record

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