National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Antioxidant activity of phenolic substances from Betulae folium.
Skálová, Miluše ; Spilková, Jiřina (advisor) ; Kašparová, Marie (referee)
ANTIOXIDANT ACTIVITY OF FENOLIC SUBSTANCES IN BETULAE FOLIUM Miluše Skálová Univerzita Karlova v Praze, Farmaceutická fakulta, Katedra farmakognozie, Heyrovského 1203, 500 05, Hradec Králové Abstract The aim of this study was to investigate antioxidant activity of exctracts of the drug Betulae folium and of buds and leaves of birch collected during the onthogenesis. Also it was appionted content of flavonoids by the method HPLC (High Performance Liquid Chromatography) and it was observed changes during the onthogenesis. The maximal content of caffeic acid in buds was similar like in leaves. The presence of chlorogenic acid was registreted in leaves which were collected in june. High content of the hyperoside was in buds before they have got blossom. and in the young leaves. The next lower maximum was in young leaves, which were collected at the end of may. This value was compareable with the content in dry leaves and also in drug of Betulae folium, which was bought in the pharmacy. The presence of kvercitrin was reminded in buds before blossoming, the similar value was in young leaves, afterthat came a huge decrease of this value. The significant content-increase of kvercitrin was reminded in dried leaves. There are significant differences between the fresh and the dried leaves of the same collection....
Antioxidant activity of herbal diuretics
Skálová, Miluše ; Spilková, Jiřina (advisor) ; Tůmová, Lenka (referee)
Mgr. Miluše Skálová The aim of this rigorous work was to specify content of flavonoids and to learn antioxidant activity of methanolic extractions of drugs, which are used as diuretics. The drugs, which were tested: Epilobii herba, Equiseti herba, Ononidis radix and the tea mixture Nephrosal. In order to test antioxidant activity it was used free radical 2, 2-difenyl-1-pikrylhydrazyl (DPPH). To compare the antioxidant activity, it was calculated value IC50, which clarificates the amount of extract, which is required for retrenchment of 50 % free radical DPPH. The lowest antioxidant activity was registrated in methanolic extracts of drug Ononidis radix from Ononis spinosa IC50=29,1049 mg/ml and in extracts of drug Ononidis radix from Ononis arvensis IC50=13,7670 mg/ml. Comparable antioxidant activities had methanolic extract of Equiseti herba IC50=3,5856 mg/ml and the tea mixture Nephrosal IC50=2,2856 mg/ml. The drug Epilobii herba has the highest values of antioxidant activity, IC50=0,3191 mg/ml. Next purpose of this work was to determine the content of flavonoids in these drugs. The lowest content was registrated in the extract of Ononidis radix (0,1657%). The highest content was registrated in the extract of Equiseti herba (0,8147%) and in the tea mixture Nephrosal (0,9308%). Epilobii herba had...
Antioxidant activity of phenolic substances from Betulae folium.
Skálová, Miluše ; Spilková, Jiřina (advisor) ; Kašparová, Marie (referee)
ANTIOXIDANT ACTIVITY OF FENOLIC SUBSTANCES IN BETULAE FOLIUM Miluše Skálová Univerzita Karlova v Praze, Farmaceutická fakulta, Katedra farmakognozie, Heyrovského 1203, 500 05, Hradec Králové Abstract The aim of this study was to investigate antioxidant activity of exctracts of the drug Betulae folium and of buds and leaves of birch collected during the onthogenesis. Also it was appionted content of flavonoids by the method HPLC (High Performance Liquid Chromatography) and it was observed changes during the onthogenesis. The maximal content of caffeic acid in buds was similar like in leaves. The presence of chlorogenic acid was registreted in leaves which were collected in june. High content of the hyperoside was in buds before they have got blossom. and in the young leaves. The next lower maximum was in young leaves, which were collected at the end of may. This value was compareable with the content in dry leaves and also in drug of Betulae folium, which was bought in the pharmacy. The presence of kvercitrin was reminded in buds before blossoming, the similar value was in young leaves, afterthat came a huge decrease of this value. The significant content-increase of kvercitrin was reminded in dried leaves. There are significant differences between the fresh and the dried leaves of the same collection....

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