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Transdermal Permeation in Vitro Study of Creams Containing Transkarbam 12
Dvořáková, Pavla ; Doležal, Pavel (advisor) ; Severa, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Technology Candidate Mgr. Pavla Dvořáková Consultant Doc. RNDr. Pavel Doležal, CSc. Title of Thesis Transdermal permeation in vitro study of creams containing transkarbam 12 The topics of skin barrier function and transdermal permeation enhancers, particularly their structure - action relationship, are covered in theoretical part of this work. It also deals with transkarbam 12 and its mechanism of action, transdermal application of active substances and electrical resistance as a physical unit. Experimental part of this work describes setup used for permeation in vitro experiments on pig ear skin of full thickness. The aim of this work was to find experimental evidence and interpretation of relation between electrical resistance of the skin and flux of caffeine from donor suspension or creams containing transkarbam 12 and also evaluate feasibility of the correction of the variability of the permeation experiments results using preceding infinite dose experiment. It was found that the higher the skin electrical conductivity, the higher the permeation of caffeine from donor samples. For the logarithmic approximation of the relation between caffeine fluxes from creams and skin electrical...
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The involvement of Czech volunteer doctors in the Balcan wars 1912 - 1913: Its impact and influence on the development of Balcan health care
Severa, Jan ; Pikal, Kamil (advisor) ; Šístek, František (referee)
Bachelor thesis "The involvement of Czech volunteer doctors in the Balkan wars 1912 - 1913: Its impact and influence on the development of Balkan health care" focuses on the Czech volunteer doctors during the Balkan wars 1912 - 1913 but other volunteer workers are also considered. The relations between the Czech representation and the Balkan states are presented. To explain the motivation of the volunteers the Czech pan-Slavism and the relations to other Slavic countries are briefly examined. The reactions to the outbreak of the war among the ordinary Czech citizens are mentioned, especially the financial and other support. The responses of the Austria-Hungarian authorities are presented. The concrete actions taken by the Czech doctors are examined and compared to the local habits and knowledge. Difficulties and problems faced by the doctors are also presented.
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The involvement of Czech volunteer doctors in the Balcan wars 1912 - 1913: Its impact and influence on the development of Balcan health care
Severa, Jan ; Pikal, Kamil (advisor) ; Šístek, František (referee)
Bachelor thesis "The involvement of Czech volunteer doctors in the Balkan wars 1912 - 1913: Its impact and influence on the development of Balkan health care" focuses on the Czech volunteer doctors during the Balkan wars 1912 - 1913 but other volunteer workers are also considered. The relations between the Czech representation and the Balkan states are presented. To explain the motivation of the volunteers the Czech pan-Slavism and the relations to other Slavic countries are briefly examined. The reactions to the outbreak of the war among the ordinary Czech citizens are mentioned, especially the financial and other support. The responses of the Austria-Hungarian authorities are presented. The concrete actions taken by the Czech doctors are examined and compared to the local habits and knowledge. Difficulties and problems faced by the doctors are also presented.
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Transdermal Permeation in Vitro Study of Creams Containing Transkarbam 12
Dvořáková, Pavla ; Doležal, Pavel (advisor) ; Severa, Jan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Technology Candidate Mgr. Pavla Dvořáková Consultant Doc. RNDr. Pavel Doležal, CSc. Title of Thesis Transdermal permeation in vitro study of creams containing transkarbam 12 The topics of skin barrier function and transdermal permeation enhancers, particularly their structure - action relationship, are covered in theoretical part of this work. It also deals with transkarbam 12 and its mechanism of action, transdermal application of active substances and electrical resistance as a physical unit. Experimental part of this work describes setup used for permeation in vitro experiments on pig ear skin of full thickness. The aim of this work was to find experimental evidence and interpretation of relation between electrical resistance of the skin and flux of caffeine from donor suspension or creams containing transkarbam 12 and also evaluate feasibility of the correction of the variability of the permeation experiments results using preceding infinite dose experiment. It was found that the higher the skin electrical conductivity, the higher the permeation of caffeine from donor samples. For the logarithmic approximation of the relation between caffeine fluxes from creams and skin electrical...
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