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Iron-chelating acitivity of selected alkaloids I.
Rudolfová, Tereza ; Macáková, Kateřina (advisor) ; Karlíčková, Jana (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical botanic and ecology Candidate: Tereza Rudolfová Supervisor: Ing. Kateřina Macáková, Ph.D. Title of diploma thesis: Iron-chelating activity of selected alkaloids I. (2012-2013) Iron belongs among the essential trace elements in the human body, where takes many important functions. Metabolic disorder of iron occurs as iron deficiency (anemia) or its abundance (hematochromatosis). Production of free radicals is induced while the level of iron is increased. This has been observed in patients with Alzheimer's disease. Abundance of iron is treated by chelating agents (f.e. deferoxamine). Treatment takes place by slow infusion which is time-consuming and expensive. These are reasons of looking for new substances administrated orally. Alkaloids are products of secondary metabolism of plants. Big doses are toxic for body. Some of their properties can be used for treatment in low concentration. This work focuses on chelation activity of certain isoquinoline alkaloids (allocryptopine, berberine, bulbocapnine, eschscholtzine, galantine, lykorine, californidine, protopine, sinoacutine, sculerine and stylopine). Deferoxamine has been used as a standard. Chelation of Fe2+ ions and total iron, where hydroxylamine has...
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Iron-chelating acitivity of selected alkaloids I.
Rudolfová, Tereza ; Macáková, Kateřina (advisor) ; Karlíčková, Jana (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical botanic and ecology Candidate: Tereza Rudolfová Supervisor: Ing. Kateřina Macáková, Ph.D. Title of diploma thesis: Iron-chelating activity of selected alkaloids I. (2012-2013) Iron belongs among the essential trace elements in the human body, where takes many important functions. Metabolic disorder of iron occurs as iron deficiency (anemia) or its abundance (hematochromatosis). Production of free radicals is induced while the level of iron is increased. This has been observed in patients with Alzheimer's disease. Abundance of iron is treated by chelating agents (f.e. deferoxamine). Treatment takes place by slow infusion which is time-consuming and expensive. These are reasons of looking for new substances administrated orally. Alkaloids are products of secondary metabolism of plants. Big doses are toxic for body. Some of their properties can be used for treatment in low concentration. This work focuses on chelation activity of certain isoquinoline alkaloids (allocryptopine, berberine, bulbocapnine, eschscholtzine, galantine, lykorine, californidine, protopine, sinoacutine, sculerine and stylopine). Deferoxamine has been used as a standard. Chelation of Fe2+ ions and total iron, where hydroxylamine has...
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