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The role of cholinergic system in spatial cognition in rats
Klečáková, Kristýna ; Klement, Daniel (advisor) ; Randáková, Alena (referee)
The studies concentrated on spatial orientation are very popular in these days. Based on its results we can determine relations between cognitive behaviour and neural structures to find out principle of various deficits observed within neurodegenerative diseases (Alzheimer, Parkinson, schizophrenia,…), with usage of animal models. Large amount of experiments are focus on potential pharmacological substances that could revert damages of these diseases. Such experiments use special mazes where spatial tasks take place. Many different modifications of these arenas allow us to observe different types of used spatial orientation and associated processes (memory, attention, learning abilities...). Big progress for research of this field was also invention of microdialysis, that allow us to get information from extracellular brain space during task performance. Key words: cholinergic system, spatial orientation, cognitive map, place cells, nicotinic receptor, muscarinic receptor, Alzheimer's disease, baso-cortical pathways
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