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Voltammetric Determination of Anticancer Drug Flutamide and Its Metabolite 4-Nitro-3-trifluoromethylaniline
Radová, Jitka ; Barek, Jiří (advisor) ; Dejmková, Hana (referee)
The subject of this Diploma Thesis has been the study of electrochemical behavior of anticancer drug flutamide (FLD) and one of its metabolites 4-nitro-3-trifluoromethylaniline (NTMA). The aim was to find and define the optimum conditions for the determination of both compounds at a mercury meniscus modified silver solid amalgam electrode (m-AgSAE) and at a carbon film electrode (CFE) using DC voltammetry (DCV) and differential pulse voltammetry (DPV). This Diploma Thesis follows closely the Bachelor Thesis, defended at the Department of Analytical Chemistry, Faculty of Science, Charles University in Prague. In this Bachelor Thesis, a voltammetric determination of FLD using DCV and DPV at m-AgSAE has been described, with attained limits of quantification (LQs) 5.0·10-6 mol.dm-3 (for DCV) and 3.0·10-6 mol.dm-3 (for DPV). In presented Diploma Thesis, voltammetric behavior of NTMA has been studied in dependence on the pH of the medium of Britton-Robinson (BR) buffer-methanol (9:1). The optimum conditions have been found for the determination of this substance using DCV and DPV at m-AgSAE and CFE in the cathodic area. As the optimum media, BR buffer-methanol (9:1) of resulting pHf 8.3 (for both DCV and DPV at m-AgSAE) and of pHf 5.1 (for both DCV and DPV at CFE) have been chosen. Further, the LQs have...
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Voltammetric Determination of Anticancer Drug Flutamide and Its Metabolite 4-Nitro-3-trifluoromethylaniline
Radová, Jitka ; Barek, Jiří (advisor) ; Dejmková, Hana (referee)
The subject of this Diploma Thesis has been the study of electrochemical behavior of anticancer drug flutamide (FLD) and one of its metabolites 4-nitro-3-trifluoromethylaniline (NTMA). The aim was to find and define the optimum conditions for the determination of both compounds at a mercury meniscus modified silver solid amalgam electrode (m-AgSAE) and at a carbon film electrode (CFE) using DC voltammetry (DCV) and differential pulse voltammetry (DPV). This Diploma Thesis follows closely the Bachelor Thesis, defended at the Department of Analytical Chemistry, Faculty of Science, Charles University in Prague. In this Bachelor Thesis, a voltammetric determination of FLD using DCV and DPV at m-AgSAE has been described, with attained limits of quantification (LQs) 5.0·10-6 mol.dm-3 (for DCV) and 3.0·10-6 mol.dm-3 (for DPV). In presented Diploma Thesis, voltammetric behavior of NTMA has been studied in dependence on the pH of the medium of Britton-Robinson (BR) buffer-methanol (9:1). The optimum conditions have been found for the determination of this substance using DCV and DPV at m-AgSAE and CFE in the cathodic area. As the optimum media, BR buffer-methanol (9:1) of resulting pHf 8.3 (for both DCV and DPV at m-AgSAE) and of pHf 5.1 (for both DCV and DPV at CFE) have been chosen. Further, the LQs have...
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The Analysis of KBC Group's Development
Radová, Jitka ; Dvořák, Petr (advisor) ; Kalivoda, František (referee)
The analysis of reasons, side effects and consequences of the global financial crisis in relation to KBC Group. Analysis of profit evolution of KBC Group as well as particular business units. The other indices of financial health - credit ratings, the share price, solvency. The analysis of the strongest effects on the profit decline - CDO, US and Icelandic banks, decline of prices of shares. Comparison of the closest competitors - Société Générale and Erste Group.
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Analýza struktury a objemu poplatků souvisejících s realizací operací na běžném účtu (u vybraných českých bank)
Radová, Jitka ; Tuček, Miroslav (advisor)
Charakteristika běžného účtu, možnosti stanovení cen bankovních produktů, charakteristika vybraných bankovních institucí, analýza objemu bankovních poplatků, analýza struktury bankovních poplatků, nejčastěji účtované poplatky, poplatková politika v ČR a v zahraničí, měsíční výdaje "běžného klienta" na bankovní poplatky. Hlavním cílem je zmapování struktury a výše bankovních poplatků v ČR, snaha o analýzu současné situace a východiska z ní.
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