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Environment for analyzing suspicious device
Procházka, Jan ; Martinásek, Zdeněk (referee) ; Malina, Lukáš (advisor)
This bachelor thesis focuses on a design of enviroment for analysis of a suspicious device. Such device may be for example a disc contaminated by malicious code or a mobile device. The aim of this work is to design an efficient and simple solution using open source products. The final designed environment should be capable of performing both surface and in-depth data analysis. The theoretical part offers an information related to the scope of addressed problem and includes terms such as Sandbox, Malware, Android. These are described from the point of view of understanding the analysis of malware occurring predominantly on mobile devices. The practical part describes the used hardware and software for the design of the environment and it contains examples of analyzes of the external devices contaminated by a malcode. These examples are mainly for Android mobile devices.
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Production of a form for shooting projectile
Procházka, Jan ; Kolář, Ladislav (referee) ; Kalivoda, Milan (advisor)
The bachelor thesis deals with the design and production of a mold for the production of a shooting projectile using the machining technologies. The thesis describes constructional design of the mold, production of 3D component in CAD, creation of NC code and description of the production process. In the end, statistical processing of the produced projectiles is carried out.
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Prevention and Control of working Conflicts
Štěpánková, Markéta ; Procházka, Jan (referee) ; Franková, Emilie (advisor)
This thesis elaborates basic overview of communication tools dealing with the prevention of work-related conflicts. The work examines the conflicts of tax advisers in the course of their practice and identifies gaps in communication. As an integral part of the thesis was made a survey focusing on problems in communication between a tax adviser and client. Based on these findings were suggested measures for improvement.
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Molecular detection of cercarial dermatitis causative agents
Procházka, Jan ; Leontovyč, Roman (advisor) ; Baláž, Vojtech (referee)
Human cercarial dermatitis (CD), also called Swimmer's itch appears as a skin rash caused by skin penetration by larval stages of avian schistosomes. In the Czech Republic, the most common causative agens is genus Trichobilharzia. Since 2021, monitoring of CD is a part of a mandatory testing of bathing water quality. The official method used for CD detection is collecting and examination of aquatic snails under a light source. However, this method has many disadvantages, such as time demands, low sensitivity and difficult parasite determination. These disadvantages can be overcome by usage of alternative approaches, such as molecular methods based on environmental DNA (eDNA) filtration and isothermal amplification. Hence, the main goal of this thesis was development of molecular method based on eDNA filtration and cLAMP isothermal amplification for detection of CD causative agent in water. Based on molecular analysis a conserved region of target DNA was selected to create a cLAMP assay specific for genus Trichobilharzia. The cLAMP assay was confirmed to specifically amplify the DNA of at least four species of the genus Trichobilharzia. The laboratory experiments showed a sufficient sensitivity of cLAMP assay for eDNA detection, based on DNA dilution series and cercariae filtration from water. The...
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The role of CRL4 ubiquitin ligase complex in homeostasis and regeneration of gastro intestinal tract
Daněk, Veronika ; Procházka, Jan (advisor) ; Janečková, Lucie (referee) ; Čermák, Lukáš (referee)
Ubiquitination represents a central regulatory mechanism for protein function utilization. Dysfunction of ubiquitin ligases is associated with the development of various pathological conditions. However, the full complexity of the ubiquitinating network in tissue homeostasis and carcinogenesis remains to be elucidated, limiting its potential as a therapeutic target. In my PhD project, I aimed to reveal the role of E3 ubiquitin ligases, particularly CUL4A, in the alteration of regulatory pathways that result in gastrointestinal (GIT) homeostasis disorders and tumor expansion. By using a novel semantic biclustering technique, we performed expression profiling of the E3 ubiquitin ligases and uncovered the potentially redundant features of GIT-specific ubiquitin ligases based on their tissue-specific expression and ontological relationships. Testing the identified compensatory network on the mouse model showed that genes from the same ontology group simultaneously altered their expression pattern after induced epithelial damage, exposing their complementary role during tissue regeneration. Next, I focused on CUL4A, a scaffold of the Cullin4-RING E3 ubiquitin ligase complex (CRL4). We described that CUL4A is expressed by populations of secretory cells in the small intestine and colon. CUL4A deficiency...
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Immunomodulatory potential of Sertoli cell progenitors during heart regeneration after injury in Xenopus
Žabková, Světlana ; Krylov, Vladimír (advisor) ; Procházka, Jan (referee)
The high percentage of mortality associated with cardiovascular diseases shows the importance of studying cardiac muscle regeneration. An interesting approach for heart regeneration may be the use of a cell culture of Sertoli progenitor cells and peritubular myoid cells derived from juvenile testes of Xenopus tropicalis that was named XtiSC. These cells were found to share a number of characteristics which are typical for mesenchymal stem cells. Mesenchymal stems cells are well-known for their immunomodulatory and anti-inflammatory abilities that promote heart regeneration. The goal of this master thesis was to test the immunomodulatory potential of Sertoli progenitor cells during heart regeneration after heart apex amputation in Xenopus tropicalis without macrophages. The reason for macrophages depletion was the assumption that XtiSC behave like macrophages in many aspects. Clodronate encapsulated in liposomes was chosen as a tool for macrophage depletion. It was confirmed that XtiSC can positively influence heart regeneration in a classic model of heart regeneration, but also in a model with depletion of macrophages. It was revealed that Xenopus tropicalis adults without macrophages injected with XtiCS into the hindlimb skeletal muscle 3 days before apical resection showed reduced fibronectin...
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Role of transcription factors MEIS in the origin and development of the neural crest
Fábik, Jaroslav ; Machoň, Ondřej (advisor) ; Buchtová, Marcela (referee) ; Procházka, Jan (referee)
Unique to the vertebrate embryo, neural crest cells represent a multipotent cell population that migrates throughout the body and gives rise to a multitude of different types of cells and tissues. Cranial neural crest cells populate the developing pharyngeal arches and establish skeletogenic condensations that generate the future bones and cartilages of the face and neck. Moreover, these cells send out and receive signals from adjacent tissues of non-neural crest origin, such as the mandibular epithelium and muscle precursor cells. Such reciprocal interactions give rise to organs and structures, for instance, to the tongue. The aim of this work was to elucidate the roles of homeodomain-containing MEIS transcription factors in neural crest cells and in craniofacial development, by using a mouse model with conditional inactivation of Meis2 gene in neural crest cells. We show that transcription factor MEIS2 is expressed in the medial region of the developing mandible and in the developing tongue. Conditional Meis2 inactivation using the Wnt1-Cre2 mouse strain caused mandible and tongue hypoplasia, and ectopic bone formation at the expense of tongue development. These mandibular arch anomalies were accompanied by the loss of Hedgehog signaling in the mandibular epithelium, expanded RUNX2 expression in...
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Analysis and Comparison of Power Plays at 2022 Men's World Floorball Championship and 2021 Junior's World Floorball Championship
Procházka, Jan ; Běhanová, Michaela (advisor) ; Dragounová, Zuzana (referee)
Author: Jan Procházka Title: Analysis and Comparison of Power Plays at 2022 Men's World Floorball Championship and 2021 Junior's World Floorball Championship Objectives: Purpose of the bachelor thesis is to analyse and compare the game situations with uneven number of players on the play field at 2022 Men's and 2021 Junior's World Floorball Championships. Thesis analyses the offences that lead to power plays. Methods: The main method is indirect observation of power plays from match replays at the 2021 Junior's World Championship and 2022 Men's World Championship, their analysis and statistical comparison. Results: Results of the thesis are knowledges about the power plays at the 2021 World Junior's Championships and the 2022 World Men's Championships. The results present an analysis of power plays according to their success rate and shooting areas in goalscoring situations. The resulting data highlights the formations that leads to goal score and highlights the formations to defend power play. The formation with one player on the top was the most used for power play goal. Slashing recorded the most frequent incidence for penalty box ejection. These findings are used to compare between the national teams and both championships. Keywords: penalty, match, short-handed, statistics
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Virtual commissioning of the CNC milling machine tool changer
Procházka, Jan ; Bražina, Jakub (referee) ; Štěpánek, Vojtěch (advisor)
The aim of this master thesis is the virtual commissioning of the automatic tool change for the MCV 754 Quick CNC milling machine with the Sinumerik One control system. In the first part of the thesis, research in the field of CNC machine tools is presented with a focus on automatic tool changing. The second part of the thesis deals with the actual virtual commissioning procedure. The procedure maps the setting of all necessary parameters and configuration of individual programs to achieve successful virtual commissioning. In addition, the thesis describes the principle of communication between the programs (Create My Virtual Machine, TIA Portal, NX Mechatronic Concept Designer). The thesis concludes with a full virtual commissioning of the automatic tool exchange, an evaluation of the advantages and disadvantages of virtual commissioning in the software NX MCD and recommendations for practice.
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