National Repository of Grey Literature 8 records found  Search took 0.00 seconds. 
Activation and function of BH3-only proteins from the Bcl-2 family
Peterka, Martin ; Anděra, Ladislav (advisor) ; Pavlů, Barbora (referee)
The Bcl-2 (B-cell lymphoma-2) family of proteins comprises crucial regulators of apoptosis in metazoans. In mammals, Bcl-2 family members regulate mitochondrial outer membrane permeabilization (MOMP), which leads to the release of pro-apoptotic molecules from the mitochondrial intermembrane space and subsequent apoptosis. Defects in the Bcl-2 signaling can result in various pathological conditions including cancer. BH3-only proteins form a pro-apoptotic subset of the Bcl-2 family. They mainly act as sensors of various pro-apoptotic stimuli such as cytokine deprivation, genotoxic stress, activated "death receptors" and others. In mammals, over ten BH3-only proteins have been identified, eight of which have been linked to the regulation of MOMP. These "conventional" BH3-only proteins are Bim, Bid, Puma, Noxa, Bad, Hrk, Bik and Bmf. This thesis provides an overview of their origin, structure, activation and involvement in apoptosis.
Marketing communication of FIBA World Championship for Women 2010
Peterka, Martin ; Šíma, Jan (advisor) ; Blažek, Daniel (referee)
Title: Marketing Communication of FIBA Women Basketball Championship 2010 Goal: The goal of my thesis is to describe marketing communication during the World Women Championship 2010 on the basis of observation and my own activity. The thesis should be able to describe different parts of marketing communication during the sport event. The goal is to create the instruction for one of possibilities, how to form marketing communication of a sport event with the help of the establishment description and the existence of marketing communication. Methods: The main method is descriptive analysis. The work uses evaluation proposal and demonstration, as well. SWOT analysis is made of found data. Results: The theses proved that all parts of marketing communication should be mutually connected and consider each other. It deals mainly with Public Relations which focus first of all on reaching needed popularity. Specialised and mass media are used. Information flow from a sport organisation to media representants should keep the balance between the quality and the quantity. Key words: marketing communication, basketball, SWOT analysis.
Charakterizace TRAILem indukované, receptor-specifické signalizace v nádorových buňkách.
Peterka, Martin ; Anděra, Ladislav (advisor) ; Rohlena, Jakub (referee)
TNF-related apoptosis-inducing ligand (TRAIL) is a member of TNF family expressed mainly by hematopoietic cells. TRAIL brought significant attention mainly for its ability to trigger apoptosis in a number of cancer cells. In addition to apoptosis, TRAIL can induce several other signaling pathways such as activation of MAP kinases or canonical NF-B signaling. Human TRAIL can bind to five receptors but only two of them (death receptors TRAIL-R1/DR4 and TRAIL-R2/DR5) can trigger TRAIL-mediated apoptotic and non-apoptotic signaling in target cells. Both receptors are ubiquitously expressed on normal and cancer cells, but the relative contribution of DR4 and DR5 to TRAIL-induced signaling is not well known. Using DR4/DR5-specific variants of TRAIL, we examined how individual receptor contributes to the induction of apoptosis and NF-B, JNK, p38, ERK1/2 and TAK1 signaling pathways in selected colorectal cells. We found that in DLD-1 cells, apoptosis and activation of JNKs are mainly mediated by DR4-selective ligand. In TRAIL-resistant HT-29 cells, we show that though DISC formation and activation of caspase-8 proceeds mainly via DR4-specific signaling, activation of NF-B pathway is mainly triggered by DR5 selective ligand. In other cells and analyzed signaling pathways both receptor-specific ligands triggered very...
Marketing communication of FIBA World Championship for Women 2010
Peterka, Martin ; Šíma, Jan (advisor) ; Blažek, Daniel (referee)
Title: Marketing Communication of FIBA Women Basketball Championship 2010 Goal: The goal of my thesis is to describe marketing communication during the World Women Championship 2010 on the basis of observation and my own activity. The thesis should be able to describe different parts of marketing communication during the sport event. The goal is to create the instruction for one of possibilities, how to form marketing communication of a sport event with the help of the establishment description and the existence of marketing communication. Methods: The main method is descriptive analysis. The work uses evaluation proposal and demonstration, as well. SWOT analysis is made of found data. Results: The theses proved that all parts of marketing communication should be mutually connected and consider each other. It deals mainly with Public Relations which focus first of all on reaching needed popularity. Specialised and mass media are used. Information flow from a sport organisation to media representants should keep the balance between the quality and the quantity. Key words: marketing communication, basketball, SWOT analysis.
Activation and function of BH3-only proteins from the Bcl-2 family
Peterka, Martin ; Anděra, Ladislav (advisor) ; Pavlů, Barbora (referee)
The Bcl-2 (B-cell lymphoma-2) family of proteins comprises crucial regulators of apoptosis in metazoans. In mammals, Bcl-2 family members regulate mitochondrial outer membrane permeabilization (MOMP), which leads to the release of pro-apoptotic molecules from the mitochondrial intermembrane space and subsequent apoptosis. Defects in the Bcl-2 signaling can result in various pathological conditions including cancer. BH3-only proteins form a pro-apoptotic subset of the Bcl-2 family. They mainly act as sensors of various pro-apoptotic stimuli such as cytokine deprivation, genotoxic stress, activated "death receptors" and others. In mammals, over ten BH3-only proteins have been identified, eight of which have been linked to the regulation of MOMP. These "conventional" BH3-only proteins are Bim, Bid, Puma, Noxa, Bad, Hrk, Bik and Bmf. This thesis provides an overview of their origin, structure, activation and involvement in apoptosis.
The Current Financial Crisis and Its Impact on International Trade
Peterka, Martin ; Drozen, František (advisor) ; Marková, Jana (referee)
The thesis is aimed at explanation of the factors that led to the creation of the current financial crisis in their mutual context. Emphasis is placed on the way of providing mortgages in the USA, policy of FED and credit derivatives. The impacts of the crisis on banking, stock and commodity markets, building industry and automotive industry are discussed as important determinants of international trade. It is shortly mentioned how countries like Germany, China or Czech Republic dealt with the crisis. The final part of the thesis is devoted to the impacts of the crisis on international trade, these impacts result from the issues that are described in the first two parts. Discussed are the commodity and territorial structures of the international trade during the years of crisis. Also the impacts on the foreign trade of the Czech Republic are stressed.
Investments into the precious metals and stones
Peterka, Martin ; Drozen, František (advisor) ; Drozenová, Alice (referee)
Práce se zaměřuje na oblast drahých kovů a kamenů z hlediska jejich využití k investičním účelům. Zabývá se základními charakteristikami jednotlivých druhů drahých kovů a kamenů, způsoby jejich využití v hospodářství, strukturou trhu s nimi, vývojem ceny s důrazem na hlavní cenové výkyvy, jejich příčiny a důsledky. Dále jsou zmíněny oblasti jejich těžby a společnosti těžbu provádějící. Největší část práce je věnována investičním instrumentům spojeným s drahými kovy a kameny, trhům, na nichž jsou obchodovány, a jejich dostupnosti a vhodnosti pro drobné investory.

See also: similar author names
6 PETERKA, Michal
4 Peterka, Matěj
6 Peterka, Michal
1 Peterka, Milan
3 Peterka, Miroslav
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