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Function of sigma factors in strains of genus Rhodococcus
Nový, David ; Štěpánek, Václav (advisor) ; Sudzinová, Petra (referee)
Thanks to their large genome sizes, rhodococci share considerable biotechnological potential, however, there is still little known about the regulation of gene expression during the initiation of transcription process. The knowledge of this process might help to optimize biotechnological application. A large number of sigma factors are involved in the transcriptional regulation of rhodococci and this number often positively correlates with their genome sizes. Sigma factors can be potentially divided into two groups: the first, conserved factors that may in some variants occur in many different species among bacteria, and the second, specific sigma factors, that have been evolutionarily selected in individual strains due to environmental and lifestyle conditions. All sigma factors present in rhodococci belong to the σ70 family and can also be divided into four groups according to the presence of conserved structural domains (groups 1 to 4). A special type of sigma factors with extracytoplasmic function (ECF, group 4) are factors carrying specific domains at their C-terminus, namely NTF- 2-like or TPR, whose functions are still not fully understood. Very little information about the physiological functions of individual sigma factors in rhodococci has been published but it can be supplemented by...
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