National Repository of Grey Literature 164 records found  previous11 - 20nextend  jump to record: Search took 0.00 seconds. 
Perception of parental allowance from the parents' in intact families perspective
Nováková, Veronika ; Hejzlarová, Eva (advisor) ; Štěpánková Štýbrová, Martina (referee)
The main goal of this bachelor thesis is to describe how parental allowance is perceived in complete families. Due to the comparison of individual respondents, incomplete families, in which men or women who take care of a child independently, are not included in the sample. The parental allowance is one of the most important benefits provided by the state social support system, and its main task is to improve the financial situation of families with children. In addition to the parental allowance, this bachelor thesis also describes the system of social support, and other benefits whose purpose is to improve the financial situation of families in the Czech Republic. It also focuses on qualitative interviews with representatives of these families who receive parental allowance. Based on the analysis of these interviews, it describes how the interviewed families manage the parental allowance, how important the income is for them, and what opinions are associated with the parental allowance. The most important category which is connected with this allowance is certainty, which this regular allowance represents. Problems, which are discuss in this thesis are missing of motivational component and informations about parental allowance. Furthermore, this bachelor's thesis emphasizes the theory of special...
Study of the effect of macrocycle on intramolecular charge transfer at phthalocyanines
Bednárik, Štefan ; Nováková, Veronika (advisor) ; Miletín, Miroslav (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Štefan Bednárik Supervisor: doc. PharmDr. Veronika Nováková, Ph.D. Consultant: PharmDr. Jiří Demuth, Ph.D. Diploma thesis: Study of the effect of macrocycle on intramolecular charge transfer at phthalocyanines Porphyrazine derivates phthalocyanines (Pcs) and their aza-analogues (AzaPcs) have been largely investigated in number of applications due to their unique photophysical and photochemical properties. One of the investigated research areas involves intramolecular charge transfer (ICT) - deactivation of excited states. This phenomenon is a competitive pathway to fluorescence emission and requires electron donors as peripheral substituents while the macrocyclic core serves as electron acceptor. The aim of this work was to study how modifications to the Pc macrocycle will affect its electron acceptor properties and subsequently the strength of ICT. The synthesis involved preparation of suitable precursors, i.e. 4,5-disubstituted phthalonitriles or 5,6-disubstituted pyrazine-2,3-dicarbonitriles. It was followed by their cyclotetramerization leading to the mixture of six different congeners, from which the desired asymmetrical ABBB type macrocycle was...
Synthesis and study of subphthalocyanines axially modified with an amino adamantyl
Danková, Eva ; Nováková, Veronika (advisor) ; Demuth, Jiří (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate Eva Danková Supervisor doc. PharmDr. Veronika Nováková, Ph.D. Title of Thesis Synthesis and study of subphthalocyanines axially modified by amino adamanthyl Photodynamic therapy is a promising approach for cancer treatment that relies on the administration of a photosensitizer, followed by illumination of the tumor. The generated oxidative stress subsequently activates several mechanisms of cell death. One of the novel groups of photosensitizers are subphthalocyanines with a conical π surface, which renders them less prone to aggregation and offers the possibility to tune their properties through axial substitution (aside peripheral modification). Due to the lipofilicity of the macrocycle, it is necessary to increase its water solubility. This work focused on the possibility of forming supramolecular host-guest complexes with hydrophilic macrocycles in order to increase the hydrophilicity of a subphthalocyanine. In particular, cucurbituril-7 (CB[7]) was chosen since it forms one of the most stable supramolecular interactions in water with 1-aminoadamantane, which was therefore proposed as the axial substituent on subphthalocyanine core. Synthesis of the...
Oxidation of a psychoactive substance fluoromethoxyacetyl fentanyl
Krejčí, Michaela ; Kubíček, Vladimír (advisor) ; Nováková, Veronika (referee)
7 2. ABSTRACT Fluoromethoxyacetyl fentanyl (FMAcF) is a new psychoactive substance that belongs to the group of newly illegally synthesized fentanyl derivatives that have been entering the European drug market since 2009. The aim was to define the electrochemical behavior of FMAcF and to suggest possible oxidation mechanisms. In this research, the electrochemical methods and in situ UV-Vis spectroelectrochemistry were used to study drug oxidation and reduction mechanism. Electrochemical techniques were combined with high performance liquid chromatography with diode array detector. FMAcF in the aqueous medium provided a single oxidation peak whose potential depended on pH. The substance was not reduced under the studied conditions. UV-Vis spectroelectrochemistry showed the formation of a reaction intermediate. The substance was electrolyzed and the UV-Vis absorption spectra of the products were determined. The oxidation mechanism of the substance has been proposed. In future the incubation with liver microsomes will be performed to detect metabolic pathways. Key words: Cyclic voltammetry, Oxidation, Bioactive substance, Fentanyls, Fluoromethoxyacetyl fentanyl
Synthesis and evaluation of N-pyridylbenzamides as potential antimicrobial compounds
Suchánková, Eliška ; Zitko, Jan (advisor) ; Nováková, Veronika (referee)
SYNTHESIS AND EVALUATION OF N-PYRIDYLBENZAMIDES AS POTENTIAL ANTIMICROBIAL COMPOUNDS Eliška Suchánková Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic The derivatives of N-pyridylbenzamide were designed and synthesized to be in vitro tested for antimycobacterial activity against Mycobacterium tuberculosis H37Ra, M. smegmatis, M. aurum and in vitro cytotoxicity in HepG2 cells. These compounds are pyridinyl analogues of previously prepared N-pyrazinylbenzamides that have shown a significant in vitro antimycobacterial activity. The title compounds were synthesized by acylation of aminopyridine or chloropyridine-2-amine by selected benzoyl chlorides. Final compounds were described by elementary analysis, melting point, 1 H and 13 C spectra and IR spectroscopy. Generally, prepared compounds possess lower antimycobacterial activity than previously tested N-pyrazinylbenzamides. However, there are some cases, in which the derivatives of pyridine were more effective compared to the derivatives of pyrazine; mainly against M. smegmatis. The best antimycobacterial activity was proved for derivatives of 2-amino-6-chloropyridine and substituted benzoyl chloride, corresponding with higher lipophilicity of these compounds;...
The death of Tsar Nicholas II and its reverberations in contemporary Czech environment
Nováková, Veronika Kateřina ; Čechura, Jaroslav (advisor) ; Šmíd, Marek (referee)
The main goal of the bachelor thesis "The death of Tsar Nicholas II and its reverberations in contemporary Czech environment" is to paint a compehensive picture of the death of the family of Russia's last Tsar and its reverbations in former Czechoslovakia. The text recounts the life and reign of Nicholas II with a closer focus on the murder of all family members in July 1918. It places the last moments of the Tsarist regime along with its sovereign in the context of contemporary Czech environment. It delves into the reverbations of Tsar's death and the coming of a new regime in Czech press, and the cultural and political scenes.
Miniaturized and fast method for solubility and level of supersaturation determinations of drug nanocrystals
Paľová, Romana ; Nováková, Veronika (advisor) ; Kuchařová, Monika (referee)
Title of thesis: Miniaturized and fast method for solubility and level of supersaturation determinations of drug nanocrystals Author: Romana Paľová Department: Biophysics and Physical Chemistry Supervisor: Doc. Veronika Nováková, Ph.D. Specialized supervisor: Assoc. Prof. Leena Peltonen, Ph.D. As a formulation strategy for improving the bioavailability of poorly water-soluble drugs, drug nanocrystals can be employed. Several studies have shown that drug nanocrystals exhibit higher dissolution rate compared to conventional drug formulations. However, when orally administered, various conditions in gastrointestinal tract, such as changes in pH may result in problematic absorption. In this work, the preparation of drug nanosuspension of itraconazole (ITZ), as model poorly water-soluble compound, was carried out. The nanosuspension was prepared by using wet milling method of preparation, with suitable stabilizers added (Poloxamer 407 and Hydroxypropyl methylcellulose). Hydrochloric acid buffer pH 1.2 was chosen to create an environment similar to gastric fluids. In order to investigate changes in solubility of ITZ nanosuspension, UV spectrophotometer was used. Measurement was performed at the wavelength 551 nm, where dissolved ITZ does not absorb light and no change in absorbance occurred....
Benzodiazines as compounds with potential bronchodilatory effect
Ježková, Věra ; Špulák, Marcel (advisor) ; Nováková, Veronika (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Věra Ježková Consultant: PharmDr. Marcel Špulák, PhD. Title of Thesis: Benzodiazines as compounds with potential bronchodilatory effect The most active compounds from previous screening contained (piperidine-1-yl)propyl moiety attached to quinazoline or quinoxaline rings. The goal of this project was to introduce hydroxyl into the three-membered carbon linker with a possibility of further modification. The synthesis was carried out employing the reaction of commercially available quinazolinone and racemic epichlorohydrin leading to epoxide which undergoes nucleophilic attack resulting in hydroxyquinazolinones. Similarly, this reaction sequence was applied on quinoxalinone. However, the attempts with sulphur analogue of quinazolinone and quinoxalinone failed. All prepared compounds have been evaluated for their bronchodilatory activity. The results indicated similar level of bronchodilatory effect as their precursors, except one with cyclohexylamine ring, which showed higher bronchodilatory effect.
Synthesis of low-symmetry azaphthalocyanine for the labeling of DNA probes increasing the susceptibility of the molecular-biological methods
Schimmerová, Aneta ; Nováková, Veronika (advisor) ; Miletín, Miroslav (referee)
1. ABSTRACT Charles University, Faculty of Pharmacy in Hradec Králové Department Department od Biophysics and Physical Chemistry Student Aneta Schimmerová Supervisor Assoc. Prof. PharmDr. Veronika Nováková, Ph.D. Title of thesis Synthesis of low-symmetry azaphthalocyanine for the labeling of DNA probes increasing the susceptibility of the molecular- biological methods Azaphthalocyanines (AzaPc) are planar macrocyclic compounds. The alkylamino substituted derivatives can be used as dark quenchers in DNA-hybridization assays. A probe usually contains a quencher and a fluorophore. If these two moieties are close enough, the emitted fluorescence is quenched by the quencher. After the hydrolysis of the oligonucleotide probe, the fluorescence appears because of the long distance between the quencher and fluorophore. Thanks to the large system of conjugated double bounds, AzaPc absorb over a wide range of wavelengths from 300 nm to 750 nm. Such absorption covers all fluorophores used in hybridization assays nowadays, thus AzaPc may serve as universal dark quenchers. The aim of this study was to prepare an AzaPc, that will be possible to attach inside an oligonucleotide strand. Furthermore, a planar moiety bounded to AzaPc will intercalate into DNA and improve the strength of binding of the probe to DNA. First, the...

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