National Repository of Grey Literature 28 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Measuring and Evaluating Company Performance Using Comparison between Companies
Novák, Jaromír ; Heralecký, Tomáš (referee) ; Kocmanová, Alena (advisor)
This bachelor’s thesis is aimed at the evaluation of the financial performance of the company FRAENKISCHE CZ s.r.o. and comparing it with the competitor LUNA PLAST a.s.The comparsion between these two companies is made in the period from 2018 to 2020 and then the improvement proposal is submitted. The work is divided into three parts. In the first one, theoretical, are defined concepts and the indicators of financial analysis. In the analytical part, values were calculated by using individuals indicators which were mentioned in the previous part. The final part presents the recommendations for improvement of the financial situation of the company.
Measuring and Evaluating Company Performance Using Comparison between Companies
Novák, Jaromír ; Heralecký, Tomáš (referee) ; Kocmanová, Alena (advisor)
This bachelor’s thesis is aimed at the evaluation of the financial performance of the company FRAENKISCHE CZ s.r.o. and comparing it with the competitor LUNA PLAST a.s.The comparsion between these two companies is made in the period from 2018 to 2020 and then the improvement proposal is submitted. The work is divided into three parts. In the first one, theoretical, are defined concepts and the indicators of financial analysis. In the analytical part, values were calculated by using individuals indicators which were mentioned in the previous part. The final part presents the recommendations for improvement of the financial situation of the company.
Methods of murine brain 3D imaging focusing on tissue clearing
Novák, Jaromír ; Drbal, Karel (advisor) ; Němec, Pavel (referee)
1 ABSTRACT Many variants of microscopic techniques are the key methods for tissue structure examination in the research as well as in clinical practice. Since the vast majority of examined tissues are intrinsically opaque, it is difficult to reconstruct their 3D structure with light microscopy. However the spatial structure is inherently connected to the function of cells, tissues or whole organs. The most common approach is sample sectioning to the thin layers, which are subsequently examined or used for 3D structure reconstruction of the sample. A different approach is to use a series of chemical reagents able to clear the samples and make them accessible for imaging via microscopy without the need for physical sectioning. Although this approach was first used more than a century ago, the widespread use of these methods came in the last few years. Since the resurgence of tissue clearing method a lot of new principles how to clear the samples were discovered as well as many new chemical compounds can be used for this purpose.. Clearing methods are becoming more and more sophisticated: the volume of samples which can be cleared is continuously growing, new methods are becoming faster and automated, the quality of after-cleared tissues is improving and compatibility with many stains including antibodies is...
Immunoscore in 3D tissue
Novák, Jaromír ; Drbal, Karel (advisor) ; Procházka, Jan (referee)
Solid tumors are complex structures comprising besides the cancer cells vasculature, extracellular matrix (ECM), soluble molecules and a plethora of various other cell types. These components form a so-called tumour microenvironment. From the numerous cell types that are part of tumor microenvironment, tumor infiltrating lymphocytes (TILs) play a major role in patient prognosis. Their presence is also of major importance with regard to new biological therapies based on immune checkpoint inhibitors. Crucial role of TILs is also reflected by the new approaches in cancer diagnostics namely by Immunoscore method (currently used in clinical settings). Immunoscore is based on localization and quantification of CD3+ and CD8+ TILs in thin histological sections of tumor tissue. The question remains to which extent the information obtained from 2D slices reflects the situation in tumor microenvironment considering its spatial heterogeneity. The development of new methodological approaches allowing evaluation of histological information in 3D is the key to answer this question. The theoretical part of this work first describes the heterogeneity of the tumor microenvironment and the role of immune cells within it. Then, the role of spatial heterogeneity and its possible influence on the histopathological...
Immunoscore in 3D tissue
Novák, Jaromír ; Drbal, Karel (advisor) ; Procházka, Jan (referee)
Solid tumors are complex structures comprising besides the cancer cells vasculature, extracellular matrix (ECM), soluble molecules and a plethora of various other cell types. These components form a so-called tumour microenvironment. From the numerous cell types that are part of tumor microenvironment, tumor infiltrating lymphocytes (TILs) play a major role in patient prognosis. Their presence is also of major importance with regard to new biological therapies based on immune checkpoint inhibitors. Crucial role of TILs is also reflected by the new approaches in cancer diagnostics namely by Immunoscore method (currently used in clinical settings). Immunoscore is based on localization and quantification of CD3+ and CD8+ TILs in thin histological sections of tumor tissue. The question remains to which extent the information obtained from 2D slices reflects the situation in tumor microenvironment considering its spatial heterogeneity. The development of new methodological approaches allowing evaluation of histological information in 3D is the key to answer this question. The theoretical part of this work first describes the heterogeneity of the tumor microenvironment and the role of immune cells within it. Then, the role of spatial heterogeneity and its possible influence on the histopathological...
Utilization of Financial Analysis as a Tool for Investment Decisions
Málek, Jiří ; Novák, Jaromír (referee) ; Ptáček, Roman (advisor)
This diploma thesis on the topic "Use of financial analysis as an instrument of investment decision-making" processes the financial evaluation of the economy and the effectiveness of selected investment decisions in the past years using methods of financial analysis. For this purpose, I chose the monitored period from 2012 to 2018. In the first part of the thesis, attention is paid to the evaluation of performance and financial sustainability in terms of implemented and planned investments of the theoretical base. The methods and analyzes used also include the methodology of their calculation. The second part deals with the individual indicators applied to Škoda Auto a.s., based in Mladá Boleslav a subsidiary of the Volkswagen Group. In addition, this section addresses the approach and decision making of the management of the company on investment projects that have already been planned or are planned in the near future, and recommendations are proposed for improving.
Methods of murine brain 3D imaging focusing on tissue clearing
Novák, Jaromír ; Drbal, Karel (advisor) ; Němec, Pavel (referee)
1 ABSTRACT Many variants of microscopic techniques are the key methods for tissue structure examination in the research as well as in clinical practice. Since the vast majority of examined tissues are intrinsically opaque, it is difficult to reconstruct their 3D structure with light microscopy. However the spatial structure is inherently connected to the function of cells, tissues or whole organs. The most common approach is sample sectioning to the thin layers, which are subsequently examined or used for 3D structure reconstruction of the sample. A different approach is to use a series of chemical reagents able to clear the samples and make them accessible for imaging via microscopy without the need for physical sectioning. Although this approach was first used more than a century ago, the widespread use of these methods came in the last few years. Since the resurgence of tissue clearing method a lot of new principles how to clear the samples were discovered as well as many new chemical compounds can be used for this purpose.. Clearing methods are becoming more and more sophisticated: the volume of samples which can be cleared is continuously growing, new methods are becoming faster and automated, the quality of after-cleared tissues is improving and compatibility with many stains including antibodies is...
Contemporary Health and Safety at Work Problems and their Influence on the Functioning of an Organization
Králik, Tomáš ; Svěrák, Tomáš (referee) ; Novák, Jaromír (advisor)
This diploma thesis elaborated on the subject „Contemporary Health and Safety at Work Problems and their Influence on the Functioning of an Organization“ focuses on the description of contemporary state of Health and safety at work problems in work activities, where the source of risk is represented by chemical substances, from the point of view of a company. The thesis sets out a view of legislative definition for the mentioned topic and also the possible application of safety at work management programs. This part also includes a summary description of risk analysis methods. In the practical part of the thesis, there is an organizational directive for a fictive company engaged in chemical production made. This directive will identify possible occupational risks resulting from the manufacturing process, and it will also evaluate the amount of risk for particular work activities in conjunction with hazard factors. The next part of the thesis contains a proposal of measures for risk reduction, based upon the previously mentioned evaluation. In the final part of the thesis, the author contemplates the possibilities of health and safety at work system improvement.
Some characteristics of safe society, its risks and threats
Novák, Jaromír
Safety is essential condition of existence and development of society. Society consists of many systems and subsystems. Complexity of their behavior and their manageability is harder and harder. Scientific and technical development influences more and more whole society and has strong influence to a human behavior as main managing and managed element. Technics and technologies influence working of systems, subsystems in the positive and also negative way. New risks and threats are grooving. Things, phenomena and processes of objective reality are less manageable and by that becoming risky for society. Knowing character of development tendencies of society is harder than in the past and as a consequence of this it is harder to manage things to predict development - especially negative sides.
Evaluation of the Financial Situation of a Company and Proposals for its Improvement
Hofmann, Eduard ; Novák, Jaromír (referee) ; Bartoš, Vojtěch (advisor)
The Master’s thesis deals with the evaluation and assessment of the financial situation and of the financial health of the company BLANESTA, s.r.o. throughout the years 2008 to 2011 by means of selected methods of financial analysis. The aim of this work is to propose changes leading to the efficient use of business resources chosen on the basis of the potential problems that will arise from the evaluation of the current financial state of the company.

National Repository of Grey Literature : 28 records found   1 - 10nextend  jump to record:
See also: similar author names
59 NOVÁK, Jakub
95 NOVÁK, Jan
23 NOVÁK, Jaroslav
9 NOVÁK, Jindřich
94 NOVÁK, Jiří
47 NOVÁK, Josef
95 Novak, Jan
47 Novak, Josef
2 Novák, J.
59 Novák, Jakub
1 Novák, Jakub Štěpán
95 Novák, Jan
9 Novák, Jaromír
23 Novák, Jaroslav
9 Novák, Jindřich
94 Novák, Jiří
39 Novák, Jiří Karel
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47 Novák, Josef
95 Novák, Ján
94 Novák, Jíří
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