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Re-interpretation of Learning Enviroment
Hamrník, Ondřej ; Matoušková, Petra (referee) ; Mléčka, Jan (advisor)
Transformation of educational space running in these days all over the world. Every one is conscious that our educational system is obsolete and we have to change it. Instead of designing of new school building o choose building which is running for education for almost one hundred and fifty years. One of these building is gymnasium in Hradec Kralove
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Újlak - Psychiatric Hospital
Valeková, Ivana ; Matoušková, Petra (referee) ; Mléčka, Jan (advisor)
The aim was to design a new conception for both new building of psychiatric hospital and psychiatric cure on the other hand. Site is based in Velke Zaluzie, villacee in the southwestern Slovakia. Placed in site of historically protected park with a dominant building of the Old Esterhazy Mansion uses principles from moder psychiatry and space modularity to ideal inter-building connections. With high sustainability aspect a new organisation of the site was created on the whole area of the park with new functions for existing buildinge and less dominant based structure od psychiatric hospital.
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Renewal of Old Brno District
Sopoušková, Petra ; Matoušková, Petra (referee) ; Mléčka, Jan (advisor)
The work deals with the development of the Old Brno District . Old Brno District is currently marked by waiting for the implementation of the land use plan, which should solve the problem of traffic. The implementation, however, will probably take a few decades. I propose to use the period of time before the change of traffic routes and begin a gradual development that will prefigure target form of the district. Well-designed architecture and urbanism is not the only condition for well-functioning city. Therefore, I propose a process which should lead to the target form, but to create social, economic, ecological and aesthetic values independently of it. For this purpose vacant spaces and temporary structures are used.
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The efflux transport activity of P-glycoprotein - 9.2 fromHaemonchus contortus
Kohoutová, Kateřina ; Matoušková, Petra (advisor) ; Boušová, Iva (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Kateřina Kohoutová Supervisor: doc. Ing. Petra Matoušková, Ph.D. Title of diploma thesis: The efflux transport activity of P-glycoprotein-9.2 from Haemonchus contortus Haemonchosis is a globally widespread disease affecting small ruminants. The causative agent of the disease is the gastrointestinal nematode Haemonchus contortus, which feeds of the blood of its host. The treatment of haemonchosis with anthelmintics is complicated by the worldwide spread of resistance. One possible cause of the development of anthelmintic resistance is a decrease in anthelmintic concentration in the worm due to increased expression of P-glycoproteins from ABC transporter superfamily. The study of the transport activity of these transporters could help to understand the mechanism of resistance development and make the treatment of haemonchosis more effective. The aim of this thesis was to characterize the transport activity of P-glycoprotein-9.2 and its interaction with a selected inhibitor using a heterologous expression system. The adherent cell line HEK293 was transfected with a plasmid carrying the Pgp-9.2 gene of the Haemonchus contortus. Successful expression was verified by dot blot. Unfortunately,...
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