National Repository of Grey Literature 4 records found  Search took 0.01 seconds. 
Classification, structure and function of α-adrenergic receptors.
Makarova, Anna-Marie ; Hejnová, Lucie (advisor) ; Rudajev, Vladimír (referee)
Adrenergic receptors are ones of the most investigated receptors today. Signal transduction by adrenergic receptors is involved in stress response. Stress activates the sympathicus and the hypothalamic-pituitary-adrenal axis of autonomic nervous system. Understanding effects of this activation on adrenergic signalisation is important for affection of the "fight of flight" reaction. Affecting the activity of sympathetic nerve sis important subject of interest in pharmacology and many drugs are developed using this actions. This thesis deals with a group α-adrenergic receptors and its subtypes. One part is devoted to structure which is subject of many explorations recently especially. Next chapter focuses on signal transduction mediated by α-adrenergic receptors. The last section refers to multitude of physiologic functions induced by these receptors. Powered by TCPDF (www.tcpdf.org)
The effect of antimicrobial peptides on Saccharomyces cerevisiae and other yeast species
Makarova, Anna-Marie ; Hodek, Petr (advisor) ; Malcová, Ivana (referee)
The increased use of antibiotics, antifungal agents and disinfectants in the last decades has resulted in development of microbial resistance to these drugs. Candida species are the fourth most common cause of hospital-acquired bloodstream infection and kill 40% of those patients. Natural antimicrobial peptides are promising candidates for the development of new agents to treat yeast and bacterial infections, as their presumed mechanism of action differs significantly from the mechanism of action of current drugs. This work is focused on several peptides isolated from the venom of wild bees and their synthetic analogues and the identification of the most effective ones against non-pathogenic Saccharomyces cerevisiae and several pathogenic Candida species. Antifungal activity of eight cationic antimicrobial peptides was tested and compared under various conditions. The overall susceptibility of pathogenic yeast species to currently used antifungal drugs and the antimicrobial peptides was screened with the aim to identify potential synergistic and species-specific effects. The effect of antimicrobial peptides on membrane potential was measured by a fluorescent probe (diS-C3(3)), and the relative hyperpolarization of plasma membrane was shown for each peptide. The effect of antimicrobial peptides on...
The effect of antimicrobial peptides on Saccharomyces cerevisiae and other yeast species
Makarova, Anna-Marie ; Hodek, Petr (advisor) ; Malcová, Ivana (referee)
The increased use of antibiotics, antifungal agents and disinfectants in the last decades has resulted in development of microbial resistance to these drugs. Candida species are the fourth most common cause of hospital-acquired bloodstream infection and kill 40% of those patients. Natural antimicrobial peptides are promising candidates for the development of new agents to treat yeast and bacterial infections, as their presumed mechanism of action differs significantly from the mechanism of action of current drugs. This work is focused on several peptides isolated from the venom of wild bees and their synthetic analogues and the identification of the most effective ones against non-pathogenic Saccharomyces cerevisiae and several pathogenic Candida species. Antifungal activity of eight cationic antimicrobial peptides was tested and compared under various conditions. The overall susceptibility of pathogenic yeast species to currently used antifungal drugs and the antimicrobial peptides was screened with the aim to identify potential synergistic and species-specific effects. The effect of antimicrobial peptides on membrane potential was measured by a fluorescent probe (diS-C3(3)), and the relative hyperpolarization of plasma membrane was shown for each peptide. The effect of antimicrobial peptides on...
Classification, structure and function of α-adrenergic receptors.
Makarova, Anna-Marie ; Hejnová, Lucie (advisor) ; Rudajev, Vladimír (referee)
Adrenergic receptors are ones of the most investigated receptors today. Signal transduction by adrenergic receptors is involved in stress response. Stress activates the sympathicus and the hypothalamic-pituitary-adrenal axis of autonomic nervous system. Understanding effects of this activation on adrenergic signalisation is important for affection of the "fight of flight" reaction. Affecting the activity of sympathetic nerve sis important subject of interest in pharmacology and many drugs are developed using this actions. This thesis deals with a group α-adrenergic receptors and its subtypes. One part is devoted to structure which is subject of many explorations recently especially. Next chapter focuses on signal transduction mediated by α-adrenergic receptors. The last section refers to multitude of physiologic functions induced by these receptors. Powered by TCPDF (www.tcpdf.org)

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1 Makarova, Anastasia
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