National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
The Study of Mechanisms of Hepatotoxic and Hepatoprotective Effects in a Model of Damaged Hepatocytes
Moravcová, Alena ; Lotková, Halka (advisor) ; Kmoníčková, Eva (referee) ; Kanďár, Roman (referee)
Liver damage has a variety of causes. Due to the role of liver in the metabolism of xenobiotics, liver damage is often caused by toxic substances. Despite the variety of causes, the mechanisms of damage may be common. Most often, oxidative stress is induced in the cell or important organelles are directly damaged. This leads to cell death, the initiation of an inflammatory response and the development of fibrosis. A major problem in Western civilization is Non Alcoholic Fatty Liver Disease (NAFLD), in which fat is stored in liver tissue. Steatotic hepatocytes may be more sensitive to damage compared to non-fatty ones. The study of hepatotoxicity and possible hepatoprotection requires suitable models for in vitro experiments. The first part of this work is therefore dedicated to the introduction of a model background using hepatocytes isolated from rat liver. First, we introduced a method of culturing hepatocytes in a sandwich and evaluated its benefit over cultivation in a monolayer, even for experiments lasting 48 hours, which are frequently used in our laboratory. Significant differences were recorded from day 4 of culture, when the sandwich model provides better preservation of morphological and functional parameters of hepatocytes. However, for our purposes of studying the mechanisms of...
Geography of the Local Region (using Ricany as an example)
Moravcová, Alena ; Váně, Petr (referee) ; Chromý, Pavel (advisor)
The theme of this thesis is Local Region in Education at Primary Schools in Ricany. The thesis is divided into two main parts. The first part deals with changes in education and their influence on teaching Geography: how the methods, forms of education and topics have changed. There is also a description of how the local region is included in education. There is a description of the local region, and possibilities of using the "local region" topic in education. At the end of the first part there is the summary of general objectives of teaching local region topics. The second part offers worksheets. There are four worksheets for children with the topic Local Region Ricany. There are four different problems in the local region. In the first worksheet the question is: How to demark the local region? And in which administrative unit of the Czech Republic the local region is included? The second topic is the traffic location of the local region. The third one is about suburbanization and its problems and the last topic is the creation of tourist guide for different groups of tourists. Every worksheet includes characterization of the problem in Ricany region, guide to worksheet for teachers, specific targets of the exercises which the pupils should know after they have finished the worksheets and finally the...
Health and social care of clients with schizophrenia in the Vysočina region
MORAVCOVÁ, Alena
Schizophrenia is a serious psychotic illness with a 1-1,5% prevalence. This illness is present in all cultures at all continents. The first goal of the practical part of this thesis is to find out what impact schizophrenia has on clients´ family, their social and working life as well as health and economical situation. The second goal is to find out how do clients with schizophrenia actually deal with problems brought by the illness.

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8 MORAVCOVÁ, Adéla
3 MORAVCOVÁ, Aneta
8 Moravcová, Adéla
1 Moravcová, Alberta
3 Moravcová, Alena
2 Moravcová, Alice
4 Moravcová, Alžběta
3 Moravcová, Andrea
3 Moravcová, Aneta
2 Moravcová, Anežka
8 Moravcová, Anna
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