National Repository of Grey Literature 65 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Electron beam welding of AlCoCrFeNi2.1 eutectic high-entropy alloy
Rončák, Ján ; Adam, O. ; Müller, P. ; Zobač, Martin
Eutectic high-entropy alloys have become a significantly studied type of material due to their combination of strength and ductility. However, previous research has focused primarily on manufacture, solidification behaviour and mechanical properties. Only a small part of the research has been devoted to welding. This paper is focused on evaluating the weldability of eutectic high-entropy alloy AlCoCrFeNi2.1 in the as-cast state without further heat treatment. The electron beam welding process was performed twice at the same parameters, except for the beam current. Properties such as the depth of the remelted layer, the formation of the heat-affected zone, and the presence of undesirable defects in the welded joints were observed using light and electron microscopy. At the same time, material properties in the form of microstructural stability, chemical composition, and hardness of the welded joints were evaluated.
Tolerable risk
Müller, Petr ; Vokoun, Rudolf (advisor) ; Bohuslav, Lukáš (referee)
1 Tolerable risk Abstract The theme of this diploma thesis is a tolerable risk (or allowable risk) as one of the circumstances excluding illegality in the Czech criminal law. The introductory chapter is devoted to the general principles of the circumstances excluding illegality, related institutes and to the ultima ratio principle meaning that criminal liability is a last resort. Furthermore, the individual circumstances excluding illegality and their mutual relations are examined, as we can observe similar or even identical building blocks between the circumstances definitions, which make them very similar to each other so that lay people are sometimes unable to distinguish them from one another. The following chapter deals with the tolerable risk itself - its history in Czechoslovakia and later Czechia until its explicit inclusion in the Criminal code from 2009, analysis of the current legal definition and details of individual elements that the Criminal code requires for undertaking a risk. It is also compared with foreign countries (Slovak and Polish) law, as these two states penal codes include similar articles about tolerable risk. Finally, the thesis deals with two specific fields of human activity which are frequently associated with tolerable risk - sport and health care. Pointed out are their...
Production and use of zinc alloy castings
Odehnal, Pavel ; Müller, Peter (referee) ; Pernica, Vítězslav (advisor)
The bachelor thesis focuses on the development of a literature search dealing with zinc production and its applications. The theoretical part is focused on the methods of production of pure zinc, the alloys used and the methods of processing of these alloys. Furthermore, selected branches of application of castings in industry are described. The work is supplemented by an experiment concerning the evaluation and remedy of defects occurring on the component.
Use of Hsp90 as a target of biological therapy of tumors
Bednárová, Kristína ; Bouchalová,, Pavla (referee) ; Müller, Petr (advisor)
Antibody-drug conjugates (ADCs) represent a relatively new class of highly potent anti-tumor drugs. Thanks to highly specific monoclonal antibodies, ADCs are able to deliver a cytotoxic payload directly to tumor cells and thus minimize damage to healthy cells. Therapeutic efficacy depends on the selection of an appropriate antigen that undergoes internalization upon conjugate binding. For this project, pro-oncogenic Hsp90 and c-Met were selected as potential targets. Hsp90 is a molecular chaperone that is overexpressed in tumor cells and, in addition, can be translocated to the membrane of these cells. Overexpressed Hsp90 contributes to angiogenesis, tumor cell motility or metastasis. C-Met is a receptor tyrosine kinase that plays a central role in epithelial morphogenesis and malignant transformation. Its increased activity induces pathways responsible for the proliferation, invasion and migration of malignant cells. The aim of the diploma thesis was to study the potential use of antibodies with anti-Hsp90 and anti-c-Met activities in anti-tumor therapy. The experimental part involved the purification of the EEV1-2.1 antibody with anti-Hsp90 activity and its subsequent characterization. Furthermore, it included the characterization and selection of anti-c-Met antibody clones. It was also focused on selection and optimization of the right conjugation strategy. The activity of the antibodies and their conjugates was examined by fluorescence microscopy and flow cytometry. In vivo experiments were further aimed at verifying the efficacy of ADC by monitoring the rate of inhibition of proliferation of selected tumor cell lines. The results revealed that the EEV1 antibody does not enter the cells specifically by antigen-mediated way, and is therefore not suitable for use in conjugation with a cytostatic drug. On the other hand, anti-c-Met antibody ADC conjugates exhibit high affinity for native antigen, internalization through antigen binding, and additionally inhibited proliferation of c-Met overexpressing OE33 cells.
The Right to a Fair Trial
Müller, Pavel ; Reschová, Jana (advisor) ; Antoš, Marek (referee)
The aim of this theses is "The Right to a Fair Trial." I approach this topic both as a juridicial institute, where I describe it's content, and a philosophical - moral principle which should, in my opinion, run through the whole legal proceedings. (Among other things), my personal experience in a civil legal proceeding drove me to write this theses. On account of this experience I started to ask myself whether everyone is really entitled to the right to a fair trial and if the principle is really functional and running through the whole legal process or it's just a theoretical concept, more or less executed in a legal process. Comparison as objective as possible of a fair trial concept to the real state of this right's protection is one of the main aims of the thesis. Not just a confrontation between vision and reality, but also a proposal of their converging. In the first part of the theses I present a brief description of material and formal sources of information regarding the right to a fair trial from both the Czech and European point of view. In the second part I present a summary of works dealing with this topic in the Czech Republic which have been published so far. In the third part I theoretically elaborate partial principles of this right. In the fourth, and the last part of this thesis...
On the Power of Weak Extensions of V0
Müller, Sebastian Peter ; Krajíček, Jan (advisor) ; Thapen, Neil (referee) ; Kolodziejczyk, Leszek (referee)
Název práce: O síle slabých rozšírení teorie V0 Autor: Sebastian Müller Katedra: Katedra Algebry Vedoucí disertační práce: Prof. RNDr. Jan Krajíček, DrSc., Katedra Algebry. Abstrakt: V predložené disertacní práci zkoumáme sílu slabých fragmentu arit- metiky. Činíme tak jak z modelově-teoretického pohledu, tak z pohledu důkazové složitosti. Pohled skrze teorii modelu naznačuje, že malý iniciální segment libo- volného modelu omezené aritmetiky bude modelem silnější teorie. Jako příklad ukážeme, že každý polylogaritmický řez modelu V0 je modelem VNC. Užitím známé souvislosti mezi fragmenty omezené aritmetiky a dokazatelností v ro- zličných důkazových systémech dokážeme separaci mezi rezolucí a TC0 -Frege systémem na náhodných 3CNF-formulích s jistým poměrem počtu klauzulí vůci počtu proměnných. Zkombinováním obou výsledků dostaneme slabší separační výsledek pro rezoluci a Fregeho důkazové systémy omezené hloubky. Klíčová slova: omezená aritmetika, důkazová složitost, Fregeho důkazový systém, Fregeho důkazový systém omezené hloubky, rezoluce Title: On the Power of Weak Extensions of V0 Author: Sebastian Müller Department: Department of Algebra Supervisor: Prof. RNDr. Jan Krajíček, DrSc., Department of Algebra....
Corrosion resistance of cast duplex stainless steels
Müller, Peter ; Záděra, Antonín (referee) ; Pernica, Vítězslav (advisor)
The master’s thesis deals with corrosion resistance of cast duplex steels. In the first part the corrosion mechanisms and their individual types are described, the second part characterizes the types of stainless steels in terms of their properties, use, structural components, and their impact on mechanical and corrosion properties of steels. Individual chapter is dedicated to duplex steels. In the experimental part the resistance of 1.4517 steel against pitting corrosion depending on the alloy contents and the PREN value was investigated. Four specimens graded according to PREN were cast. Supplemented with sample stirrer blade which was affected by corrosion during service they were subjected to corrosion test according to ASTM G48-11 standard in 6% FeCl3 solution. Cast specimens were subjected to tensile test and impact test.
Java Collections Performance Testing on Multicore Systems
Husar, Martin ; Müller, Petr (referee) ; Letko, Zdeněk (advisor)
This thesis deals with Java collections performance testing on multicore systems. The aim of the work is studying of core collections contained in Java Collection Framework and studying also some other collections from package java.util.concurrent and third-party project known as Javolution. The task was to suggest appropirate performance test for these collections and create based on its results a comparison. Afterwards the basic solution is an implementation of suggested tests in Java programming language and evaluation of achieved results.
Variations and other changes to public contracts under FIDIC standard forms
Müller, Petr ; Klee, Lukáš (advisor) ; Brodec, Jan (referee)
Variations and other changes to public contracts under FIDIC standard forms Abstract This thesis deals with variations and other change institutes according to the FIDIC Red Book (hereinafter referred to as "CONS") enforced under the Act No. 134/2016 Coll., On Public Procurement, as amended. The main aim of this thesis is to analyze the possibility to effectively implement complex construction projects in the Czech legal environment, especially with regard to the fact that individual complex construction projects deal with, in their implementation phase, the necessity to change the work, the price for the work, but also the time of completion and handover of a work due to unforeseeable or unforeseen circumstances. The law of public procurement, with reference to the principles of free competition and, in order to ensure the effectiveness of the management of public funds, limits the possibility of the public contract modifications by means of the doctrine of the substantial and non-substantial modification. Large construction projects often exceed the estimated value of the public contract by more than 100 %, which puts a great deal of pressure on the correct and lawful subsumption of changes under the legal grounds of modifications of the contract according to section 222 of the Act on Public Procurement....

National Repository of Grey Literature : 65 records found   1 - 10nextend  jump to record:
See also: similar author names
15 MÜLLER, Pavel
2 Müller, Patrik
15 Müller, Pavel
1 Müller, Pavol
2 Müller, Peter
16 Müller, Petr
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