National Repository of Grey Literature 4 records found  Search took 0.01 seconds. 
Multiple sclerosis - clinical and paraclinical markers for monitoring disease activity and factors influencing its course
Šťastná, Dominika ; Horáková, Dana (advisor) ; Libertínová, Jana (referee) ; Taláb, Radomír (referee)
Multiple sclerosis (MS) is a chronic neurological disease that, without treatment, leads over years to decades to severe disability in most patients. We cannot cure the disease, but there is growing evidence that early initiation of anti-inflammatory therapy and management of associated comorbidities has a major impact on its course. Patient registries have an irreplaceable contribution to evaluating factors influencing the MS course and the monitoring of therapeutic agents in real clinical practice. First, this thesis evaluated therapy management trends between 2013 and 2021 based on data from the Czech National MS Registry (ReMuS). Subsequently, the paper responds to the onset of the covid-19 pandemic through registry data and addresses this issue in the context of MS. The proportion of patients in ReMuS treated with high-efficacy disease-modifying therapies (HE-DMT) increased from 16.2% to 37.1% between 2013 and 2021, and the proportion of treatment-naive patients initiating HE-DMT increased from 2.1% to 18.5%. Regarding covid-19 infection, we determined that higher body mass index, older age, recent high-dose glucocorticoid treatment, and anti-CD20 therapy were independent variables associated with pneumonia based on data from 958 MS patients with a history of covid-19. Further, we analyzed...
Multiple Sclerosis - Neuropsychological markers for monitoring disease activity
Friedová, Lucie ; Uher, Tomáš (advisor) ; Holštajn Zemánková, Petra (referee) ; Libertínová, Jana (referee)
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that generates a wide range of clinical symptoms. These include cognitive impairment, a set of symptoms closely associated with the quality of life, which also serves as one of the most important predictors of limited ability to work. This doctoral thesis presents the output from four studies divided into three areas focusing on neuropsychological markers in connection to other manifestations and effects of MS. The first researched area is the link between speech characteristics and the information processing speed by patients with MS. Our study has proven a profound association between lower speed of articulation and below-average performance in terms of information processing speed. We have proven that acoustic quantitative speech analysis has the potential to identify patients with below-average cognitive performance. Another goal of this doctoral thesis was to ascertain the predictive value of serum neurofilament light chain levels in recently diagnosed patients with MS for the development of cognitive disorder within nine years of observation. During the period of observation, we uncovered only a loose link between high levels at the onset of the disease and the deterioration of cognitive functions in...
Boston Naming Test in preoperative examination in patients with pharmacoresistant temporal lobe epilepsy
Libertínová, Jana ; Preiss, Marek (advisor) ; Šivicová, Gabriela (referee)
Theoretical part of this thesis concems Pharmacoresistant Temporal Lobe Epilepsy and Epilepsy surgery as an important option of the treatment of these patients. lt introduces respective methods used in complex preoperative diagnostics stressing the neuropsychological preoperative examination. Majority of basic cognitive functions - memory, speech and IQ - are lateralised. Functionality of temporallobe is reflected by ability of naming. We introduce the Boston Naming Test (BNT) used in preoperative diagnostics of pharmacoresistant epilepsy patients to locate the epileptogenic region. Empirical part concems Czech adaptation and standardisation of BNT and describes pivotal study with 38 healthy persons and 38 patients with temporal lobe epilepsy. Main objective was to check criterial validity ofBNT" Statistical analysis shows highly significant differencies between scores of healthy controls and epilepsy patients. (p < 0,000). Test shows 80% sensitivity and 92% specificity.
Boston Naming Test in preoperative examination in patients with pharmacoresistant temporal lobe epilepsy
Libertínová, Jana ; Šivicová, Gabriela (referee) ; Preiss, Marek (advisor)
Theoretical part of this thesis concems Pharmacoresistant Temporal Lobe Epilepsy and Epilepsy surgery as an important option of the treatment of these patients. lt introduces respective methods used in complex preoperative diagnostics stressing the neuropsychological preoperative examination. Majority of basic cognitive functions - memory, speech and IQ - are lateralised. Functionality of temporallobe is reflected by ability of naming. We introduce the Boston Naming Test (BNT) used in preoperative diagnostics of pharmacoresistant epilepsy patients to locate the epileptogenic region. Empirical part concems Czech adaptation and standardisation of BNT and describes pivotal study with 38 healthy persons and 38 patients with temporal lobe epilepsy. Main objective was to check criterial validity ofBNT" Statistical analysis shows highly significant differencies between scores of healthy controls and epilepsy patients. (p < 0,000). Test shows 80% sensitivity and 92% specificity.

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