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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Effects of exotic plant extracts on proliferation and migration of normal human dermal fibroblasts
 Lehečková, Zdeňka ; Hronek, Miloslav (advisor) ; Herink, Josef (referee)
Background: Wound healing is a physiological and highly organized complex process leading to tissue repair after an injury. A dynamic interplay between cellular and extracellular components involved in the repair process is essential for regular wound healing, results in a restoration of tissue integrity. Samoa Islands in the South Pacific are considered one of the most preserved places in the world. Local exotic plants are widely used by indigenous people to treat various skin injuries. However, the healing skills of these traditionally used plant species have been poorly studied from a scientific point of view. Methods: We analysed the effects of 16 Samoan plant extracts for their potential wound healing properties, by assessing dermal fibroblast proliferation and migration. For the evaluation of these cellular events in vitro DNA quantification and scratch wound assay were employed. Results: Screening of all extracts showed various effect on cell proliferation and migration with a concentration dependence. Particularly, at the highest concentration 512 µg/ml were cytotoxic 8 extracts, while at the concetration 32 µg/ml expressively reduced fibroblast proliferation 3 extracts. The effects on cell migration correlated with the proliferation assay results. Based on the screening data, 3 extracts...
Detailed record
Effects of exotic plant extracts on proliferation and migration of normal human dermal fibroblasts
 Lehečková, Zdeňka ; Hronek, Miloslav (advisor) ; Herink, Josef (referee)
Background: Wound healing is a physiological and highly organized complex process leading to tissue repair after an injury. A dynamic interplay between cellular and extracellular components involved in the repair process is essential for regular wound healing, results in a restoration of tissue integrity. Samoa Islands in the South Pacific are considered one of the most preserved places in the world. Local exotic plants are widely used by indigenous people to treat various skin injuries. However, the healing skills of these traditionally used plant species have been poorly studied from a scientific point of view. Methods: We analysed the effects of 16 Samoan plant extracts for their potential wound healing properties, by assessing dermal fibroblast proliferation and migration. For the evaluation of these cellular events in vitro DNA quantification and scratch wound assay were employed. Results: Screening of all extracts showed various effect on cell proliferation and migration with a concentration dependence. Particularly, at the highest concentration 512 µg/ml were cytotoxic 8 extracts, while at the concetration 32 µg/ml expressively reduced fibroblast proliferation 3 extracts. The effects on cell migration correlated with the proliferation assay results. Based on the screening data, 3 extracts...
Detailed record

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