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Modeling and Control of AC Electric Drives during Fault Conditions
Kozovský, Matúš ; Glasberger, Tomáš (referee) ; Kuchař, Martin (referee) ; Blaha, Petr (advisor)
Dizertační práce se zabývá modelováním a řízením elektrických pohonů během poruchových stavů. Práce se obzvláště zaměřuje na více-fázové motory. První část práce se zabývá matematickými rovnicemi obecného více-fázového motoru a následným odvozením n-krát troj-fázového zapojení motoru. Modely v dq souřadnicovém systému a modely ve statorových souřadnicích jsou navrženy pro simulaci chování motoru během poruchových stavů. Další část práce se zabývá analýzou poruch ve více-fázových motorech s využitím matematických modelů. Různé vnitřní struktury vinutí motoru jsou analyzovány z pohledu možného řízení během poruchového stavu. Taktéž je prezentováno chování těchto různých struktur motoru během poruchových stavů. Předmětem analýzy jsou elektrické poruchy vinutí motoru a elektrické poruchy výkonové elektroniky. Poslední část práce se zabývá testováním navrženého řídícího algoritmu a navržených kompenzačních strategií pro poruchy na reálných motorech. Pro testování byl použit segregovaný dvakrát troj-fázový motor a experimentální motor s odbočkami pro emulaci poruch vinutí. Provedené testy prokázaly, že vhodně navrhnutý motor v kombinaci se správným řídícím algoritmem a výkonovou elektronikou dokáže zaručit kontinuální běh pohonu i během poruchy.
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Determination of masonry modulus of elasticity in the direction of bed joints
Kuchař, Martin ; Klusáček, Ladislav (referee) ; Terzijski, Ivailo (advisor)
The determination of strain properties of masonry in the direction parallel to bed joints is a fundamental pre-requisite for designing structures, where masonry is subjected to horizontal stresses (e. g. strengthening with prestressing). The diploma thesis summarized techniques of determination of masonry modulus of elasticity presented in available literature. The goal is to suggest suitable methodology of determination of masonry modulus in direction parallel to the bed joints. In the practical part of the diploma thesis is that methodology verified by experimental test and results of tests are analyzed and discussed.
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Design of Pardubice Connection from HSR Line
Kuchár, Martin ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The aim of the work was to design the railway connection of the city of Pardubice to the VRT network Prague - Hradec Králové - Wroclaw. The beginning of the connection is to be located near the village of Olešnice. The end of the connection is to be located near the village of Opočínek on a conventional line in front of the railway stop Pardubice - Opočínek. The new VRT route is to be designed for a maximum speed of 350 km / h according to the DÚR Design Manual. The length of the route should be about 20 km.
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Design of Monolithic RC Structure
Kuchař, Martin ; Zlámal, Martin (referee) ; Švaříčková, Ivana (advisor)
The bachelor’s thesis describes the design of the load-bearing part of the reinforced monolithic frame concrete structure of the home for the elderly. The subject of assessment are the typical elements of the load-bearing skeleton in the 1st floor: frame rung PS, beam T5, column SR3a and the ceiling plate above the first floor. The assessment is made for ultimate limit states, moreover for frame rung PS the deflection control is provided, too.
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Pathofysiology of a tumour microenvironment of salivary glands cancer
Kuchař, Martin ; Skřivan, Jiří (advisor) ; Pokorný, Jaroslav (referee) ; Lohynská, Radka (referee)
Treatment options for salivary gland carcinomas (SGC), especially advanced ones, are limited. Immunotherapy, particularly therapy with immune checkpoint inhibitors (ICI), has brought significant progress and change in the treatment of malignant tumors. The effect and response to immunotherapy using ICI are largely driven by the characteristics of immune cells in the tumor tissue and, as it turns out, also in the peritumoral tissue. We conducted an immunohistochemical analysis of the expression of the immune checkpoint protein PD-1 and its ligand PD-L1 on the surface of tumor cells as well as tumor-infiltrating immune cells (TIIC) in samples of salivary carcinomas, separately in their centre and at their periphery. In addition to the above, an increasing amount of evidence suggests that resistance to ICI therapy is modulated by the interaction of the Fas receptor (CD95) and Fas ligand (FasL, CD178) between tumor cells and immune cells. We therefore decided to explore the expression and interaction of Fas-FasL between tumor cells and tumor-infiltrating immune cells in the centre of the tumor and in the peritumoral area of salivary carcinoma samples. Differential evaluation of the tumor centre and tumor periphery across various histological subtypes of SGC revealed the role of peripheral TIICs and...
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Study of Tram Track Extension to the City District Brno-Bosonohy
Hozáková, Bettina ; Kuchár, Martin (referee) ; Valehrach, Jan (advisor)
This study elaborates four options of the extension of the tram track Brno-Bosonohy, which are subsequently compared according to the impact on the urban structure and the possibility of its adaptation to the street area. The thesis examines the Brno City Zoning Plan and the Bosonohy Zoning Study, its documents are used as a basis of the concept, further defines the terms of the principles of tram track design, and describes the strengths and weaknesses of the elaborated options. The study also covers the design of tram stops and a loop, as well as a potential roundabout with a tram track running through it.
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History of women's football in the Czech lands
Kuchař, Martin ; Kašpar, Ladislav (advisor) ; Pokorný, Ladislav (referee)
This bachelor thesis deals with the history of women's football in the Czech lands. The thesis is divided chronologically from the very beginnings of football as a collective sport and traces the involvement of women in the game. It defines the first sporting activities of women in society and their official educational physical education process in Europe. Provides the earliest references to women's football in Great Britain and Bohemia. Describes the most important things that have happened in women's football in the Czech territory, in a chronological sequence from the founding of the first women's team, the structure of the first regular competitions to the current structure of women's football in the Czech Republic. The most famous teams are mapped and the most important personalities of women's football in the Czech Republic and the world are described. It describes the development of the Czechoslovak women's national football team from its first official match to its isolation under the Czech flag. The chapters are enriched with contemporary interviews and public reactions from available theses, periodicals, books and websites. The original text is a chronological history of the women's league team FK Dukla Prague. In the appendices we find transcripts of interviews with women's football...
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Study of Tram Track Extension to the Modřice
Kuchár, Martin ; Bret, Ondřej (referee) ; Valehrach, Jan (advisor)
The objective of the master’s thesis is to design an extension of the tram line from the existing Komárov loop to Modřice. Part of the design is the end of the tram line in Modřice, the positioning of new stops and the interconnection to the existing line in Vídeňská street. The extension of the tram line is designed for a maximum speed of 50 km/h with possibility of increase in the future to 80 km/h in selected locations. The lenght of the line is about 6 km.
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Effects of Neurotransmission-Modulating Multipotent Compounds in Pharmacological Animal Models of Cognitive Deficit
Chvojková, Markéta ; Valeš, Karel (advisor) ; Kuchař, Martin (referee) ; Rudá, Jana (referee)
In preclinical research on Alzheimer's disease pharmacotherapy, attention is paid to multipotent compounds, enabling intensification of the effect by targeting multiple pathophysiological mechanisms. The aim of the thesis was to assess the effect of multipotent compounds and combination therapy in models of cognitive deficit in the rat. The mechanism of action of the tested compounds was modulation of neurotransmitter systems. The aim of the first part of the study was to compare the effect of experimental monotherapy and combination therapy with an N-methyl-D-aspartate (NMDA) receptor antagonist and a γ-aminobutyric acid type A (GABAA) receptor positive modulator in the trimethyltin-induced model. Superiority of the combination therapy was proven by histological analysis of hippocampal neurodegeneration; however, it did not reach statistical significance in the cognitive test. The other part of the thesis focused on multipotent tacrine derivatives. We demonstrated a positive effect of 6- chlorotacrine-6-nitrobenzothiazole hybrid, as well as 6-chlorotacrine-L-tryptophan hybrid, acting as acetylcholinesterase inhibitors, in the scopolamine-induced model of cognitive deficit. Besides, we demonstrated a low risk of serious side effects of other tacrine derivatives acting as NMDA receptor antagonists....
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Design of Pardubice Connection from HSR Line
Kuchár, Martin ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The aim of the work was to design the railway connection of the city of Pardubice to the VRT network Prague - Hradec Králové - Wroclaw. The beginning of the connection is to be located near the village of Olešnice. The end of the connection is to be located near the village of Opočínek on a conventional line in front of the railway stop Pardubice - Opočínek. The new VRT route is to be designed for a maximum speed of 350 km / h according to the DÚR Design Manual. The length of the route should be about 20 km.
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