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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
LC-MS monitoring of selected antimicrobial compounds in waters
 Krupka, Dominik ; Kučera, Radim (advisor) ; Kastner, Petr (referee)
5 Abstract Charles University Phaculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Dominik Krupka Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Consultant: Ing. Martin Ferenčík Title of diploma thesis: LC-MS monitoring of selected antimicrobial compounds in waters The monitoring of residues of human and veterinary antibiotics in surface water is gaining more and more importance due to the increasing resistance of bacteria. This work deals with the modificate of an HPLC-MS/MS method to obtain pilot data on the occurrence of antibiotics in surfaces water. The method is focused on the analysis of 30 antibiotics from the groups of β-lactams, macrolides, lincosamides, amphenicols, fluoroquinolones, tetracyclines and sulfonamides. The method was performed on a UHPLC instrument Agilent 1200 Infinity series with MS Agilent model 6495 triple Quad. Separation of antibiotics was performed on reverse phase using gradient elution and tandem mass spectrometry. An electrospray in both positive and negative polarity was used to ionize the analytes. The method was used for the pilot analysis of surface water samples in the Czech Republic. Samples from 15 rivers and streams were analysed. The most frequently found antibiotics were sulfomethoxazole and...
Detailed record
LC-MS monitoring of selected antimicrobial compounds in waters
 Krupka, Dominik ; Kučera, Radim (advisor) ; Kastner, Petr (referee)
5 Abstract Charles University Phaculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Dominik Krupka Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Consultant: Ing. Martin Ferenčík Title of diploma thesis: LC-MS monitoring of selected antimicrobial compounds in waters The monitoring of residues of human and veterinary antibiotics in surface water is gaining more and more importance due to the increasing resistance of bacteria. This work deals with the modificate of an HPLC-MS/MS method to obtain pilot data on the occurrence of antibiotics in surfaces water. The method is focused on the analysis of 30 antibiotics from the groups of β-lactams, macrolides, lincosamides, amphenicols, fluoroquinolones, tetracyclines and sulfonamides. The method was performed on a UHPLC instrument Agilent 1200 Infinity series with MS Agilent model 6495 triple Quad. Separation of antibiotics was performed on reverse phase using gradient elution and tandem mass spectrometry. An electrospray in both positive and negative polarity was used to ionize the analytes. The method was used for the pilot analysis of surface water samples in the Czech Republic. Samples from 15 rivers and streams were analysed. The most frequently found antibiotics were sulfomethoxazole and...
Detailed record

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