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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Optimization of the Synthesis of 3-(4-Bromophenyl)-5-hydroxymethyl-5,6-dihydro- pyran-2-one
 Krenk, Ondřej ; Pour, Milan (advisor) ; Klimešová, Věra (referee)
Treatment of cancer still requires searching of new antineoplastics. Studies of biological activity of natural produkts show, that wide spektrum of biological aktivity have α,β- unsaturated-δ-laktons as potential substance with cytostatik aktivity. Goal of this work is optimalization of synthesis of 3-(4-bromfenyl)-5-hydroxymethyl-5,6-dihydro-2H-pyran-2-one as analogue of biologically active substance with potential cytostatic effect against cell line of colorectal carcinoma. Results obtained from this work can be employed in the development of simplier and more economical synthesis of potential biologically active analogues of α,β- unsaturated-δ-lactones.
Detailed record
Optimization of the Synthesis of 3-(4-Bromophenyl)-5-hydroxymethyl-5,6-dihydro- pyran-2-one
 Krenk, Ondřej ; Pour, Milan (advisor) ; Klimešová, Věra (referee)
Treatment of cancer still requires searching of new antineoplastics. Studies of biological activity of natural produkts show, that wide spektrum of biological aktivity have α,β- unsaturated-δ-laktons as potential substance with cytostatik aktivity. Goal of this work is optimalization of synthesis of 3-(4-bromfenyl)-5-hydroxymethyl-5,6-dihydro-2H-pyran-2-one as analogue of biologically active substance with potential cytostatic effect against cell line of colorectal carcinoma. Results obtained from this work can be employed in the development of simplier and more economical synthesis of potential biologically active analogues of α,β- unsaturated-δ-lactones.
Detailed record

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