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Adrenal function in patients with diabetes mellitus type 1 (young adults)
Šimůnková, Kateřina ; Vondra, Karel (advisor) ; Kršek, Michal (referee) ; Marešová, Dana (referee)
Background: The Addison disease of the autoimmune etiology is mostly appearing as a part of APS2 whereas the most dangerous is a combination of DM1 and an autoimmune adrenalitis. The first evidence of adrenal insufficiency in DM1 is a repetitive hypoglycaemia and lower insulin consumption. Changes in the HPA axis caused by either the activation of the immunity system during the APS2 or by the structural changes in the insulin binding proteins may present the basis for the subclinical adrenal insufficiency. The functional adrenal disorders without autoimmune adrenalitis are frequently observed in autoimmune diabetes mellitus. (...) Conclusions: A rather slow autoimmune adrenalitis progress is observed in adult patients with autoimmune endocrinopathies but rarely ending with a full adrenal destruction. The adrenal antibodies importance is still under study. Higher adrenal disorder count in DM1 patients with first manifestation around the age of 30 is presumed according to our results. Subclinical adrenal insufficiency is still very difficult to diagnose and new diagnostic ways 7 are recently being proposed. We have proven the advantages of salivary cortisol during the test as well as in daily profile. We have shown that adrenal disorders are not caused by cortisol binding peptide structure modifications in...

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1 Kršek, Martin
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